I've been taking this for 10 years for bipolar. If I heard even so much as a rumor that it was being discontinued I'd get all my money together and buy as much as I could afford. It keeps me alive! When I first started taking it, I didn't really notice any difference. So I quit. Then I suffered a severe depression. My friend, who had my bottle of Thyroid Formula, suggested I take 2. In 45 minutes I was back from the raving maniac mood to feeling quite normal. I no longer wanted to kill myself. I've been taking it every since. It has pulled me out of 3 suicidal depressions, the other two being when the doctor told me to stop taking it. I take 2 in the morning - with food, otherwise it tends to make me sick to my stomach for about 1 minute. When life gets a bit tough, I may take 1 or 2 later in the day. It has worked well for friends for episodic relief of anxiety and panic attacks, and migraine headaches. Since I've been taking Metabolic Advantage I don't get headaches. Even friends who don't think it will work on panic attacks or anxiety attacks see relief in as little as 45 minutes. Sometimes less. When I moved here, I checked out the local health food store, but they didn't carry it. The owner ordered it for me, and commented that, after researching it, it was a very good product. I heartily agree!!!