My doctor told me to take one pill before dinner and one before bedtime. FANTASTIC! If you think 5-HTP is only for getting rid of depression and to get you in a good mood or help you to sleep, think again. 5-HTP does more than that. Since serotonin levels get to their desirable point. Next, the whole body is in perfect communication thanks to the full set of neurotransmitters. The immune system also starts working at its best and there you go. In a few weeks, everything seems to be and feel like you are getting better and better. Do not forget to eat well and drink a good number of glasses of water. This is only my experience and I been taking 5-HTP for a year and a half and planning to keep it in my life.