I was prescribed HRT by my consultant some years ago and underwent the usual tests. I was assured I was the perfect subject for HRT. I began using HRT with tablets - they were awful and gave me morning sickness, bloating and joint pains and I was constantly breathless and gained around 20 lbs in weight. This continued even when I was prescribed patches and I found it difficult to breathe but the connection was never made until I collapsed with a pulmonary embolism. This apparently was caused by the HRT. Following my recovery, my 'new' consultant prescribed natural progesterone in the form of this cream to be administered daily. I felt great! I recovered from the embolism and have used this cream ever since. It stopped the hot flashes and other symptoms associated with the menopause. I have no irritation and my libido is as good as it was when I was in my twenties, probably better! I would highly recommend this product - it would appear to have no side effects, other than a feel good factor and the cream makes your skin nice and soft too.