Customer Service: 1.888.222.6056   |   Support   |   About Us
ShareShare & Earn $10
Copy and share this page with your rewards code attached, and earn $10 plus save others money. More Information
 Shopping Cart
Items in your shopping cart Quantity Price
Subtotal: $ 0.00

Brain Stem Cells Reverse Myelin Deficiency in Mice

Brain Stem Cells Reverse Myelin Deficiency in MiceBy Jeffrey Perkel
HealthDay Reporter


THURSDAY, June 5 (HealthDay News) -- Researchers report they have used neural stem cells to correct a congenital brain disorder in mice.

Dr. Steven Goldman, of the University of Rochester Medical Center in New York, and his colleagues used a type of neural stem cell called "glial progenitor cells" (GPCs), derived from human fetuses, to correct both behavioral and physiological abnormalities in a mouse model of a myelin-deficiency disorder.

The study represents "a very important advance," said Dr. James Goldman, an investigator in the Columbia Neural Stem Cell Program at Columbia University Medical Center, who was not involved in the study.

Though Steven Goldman and others previously had shown that injection of GPCs into mouse brains could lead to remyelination of demyelinated neurons, that observation did not include any change in disease progression.

"The fact that they were able to get at least some of these animals to survive, and show that physiologically and behaviorally they are doing well, is an advance," said James Goldman.

The findings were reported in the June issue of Cell Stem Cell.

Myelin is a structure, comprised of protein and fat, that envelops long neuronal fibers called axons. Axons are the conduits for neural impulses, both conscious and unconscious. Just as electrical cable must be insulated to prevent signal loss over distance, myelin ensures that nerve impulses can traverse long axonal processes in the central nervous system without degrading.

Myelin is formed by neural support cells called oligodendrocytes, which are derived from GPCs. Disorders that arise from the absence or degradation of myelin represent a "substantial proportion of adult neurological diseases," said Steven Goldman. They run the gamut from autoimmune disorders like multiple sclerosis to congenital conditions like adrenoleukodystrophy, the condition featured in the movie, Lorenzo's Oil.

In this study, Goldman and his team used "shiverer" mice, whose congenital lack of myelin basic protein causes them to shake and seize uncontrollably, giving them their name. They typically die by 5 months of age.

The shiverer mice were crossed with immunodeficient mice, so they would not reject the GPC transplant, and split into three treatment groups; 59 received no treatment, 29 received injections of buffer into five different locations in the brain shortly after birth, and 26 received injections of GPCs.

By about 130 days after birth, all 88 control mice died. But six of 26 transplanted animals survived at least 160 days, and four lived over a year. Behaviorally and physiologically, these survivors appeared largely cured, and post-mortem analysis of these animals' brains and spinal cords demonstrated why.

"The entire central nervous system had remyelinated and looked normal in terms of structural configuration of the myelination, both at the microscopic and submicroscopic level, and at the behavioral level," Goldman said.

In other words, from five separate injection sites, the GPCs migrated throughout the central nervous system, differentiated into oligodendrocytes, and began producing myelin.

The researchers then assessed the physiological effect of that remyelination, by measuring the speed of nerve transmission along remyelinated axons. They observed velocities on par with those of normal mice.

"That is proof in principle that putting glial progenitors in a brain like this will at least partially remyelinate the brain, and do so functionally," said James Goldman.

Though this study involved a congenital pediatric disorder, Steven Goldman said his goal is to apply the technique to adult diseases like multiple sclerosis. For now, his team is working to understand why most transplanted animals still die. He suggested this could stem from the seizures that plague shiverer animals, including transplant recipient

SOURCES: Steven Goldman, M.D., Ph.D., Dean Zutes Chair, professor, Neurology and Neurosurgery, chief, Division of Cell and Gene Therapy, and co-director, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, N.Y.; James E. Goldman, M.D., Ph.D., professor, pathology, and director, Division of Neuropathology, Columbia University College of Physicians and Surgeons, New York City; June 2008, Cell Stem Cell

Copyright © 2008 ScoutNews, LLC. All rights reserved.



Share This Article:




Coupons & Promotions
Sign Up
eVitamins.com, © Copyright 1999-2019. All Rights Reserved. eVitamins, LLC

eVitamins is a registered trademark of eVitamins, LLC. Statements made about specific vitamins, supplements, procedures or other items sold on or through this website have not been evaluated by eVitamins or by the United States Food and Drug Administration. They are not intended to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only. As always, please consult with a licensed doctor or physician before starting any diet, exercise or supplement program, before taking any vitamin or medication, or if you have or suspect you might have a problem.

eVitamins, LLC - 6833 Auburn, Utica, MI 48317 USA - 1-888-222-6056


Privacy Policy | Terms and Conditions