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Omeprazole: Main Image

Omeprazole is a member of the proton pump inhibitor family of drugs, which blocks production of stomach acid. Omeprazole is used to treat diseases in which stomach acid causes damage, including gastric and duodenal ulcers, gastroesophageal reflux disease, erosive esophagitis, and Zollinger-Ellison syndrome.

  • Keep up your calcium Omeprazole may interfere with your body’s ability to absorb calcium carbonate. Other forms, such as calcium citrate, may help maintain calcium levels.
  • Get extra folic acid to avoid depletion Antacids, including omeprazole, inhibit folic acid absorption, so taking 400 to 1,000 mcg of folate per day may help maintain blood levels.
  • Watch your vitamin B12 levels Omeprazole interferes with vitamin B12 absorption from food, though not from supplements, so people taking this drug might need 10 to 50 mcg of vitamin B12 per day or have their vitamin B12 status checked yearly.
  • Drink cranberry juice with your meals When taking omeprazole, consider drinking acidic liquids such as cranberry or grapefruit juice with foods that contain vitamin B12 to increase its absorption.
  • Maintain your vitamin C Omeprazole may decrease the amount of vitamin C in your blood, so take 250 to 500 mg daily to avoid depletion.
  • Use St. John’s wort when using omeprazole St. John's wort may significantly decrease blood levels of this drug, accelerating its metabolism in the body and making it less effective.

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.

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