One preliminary trial found that adding 600 mg NAC three times per day to interferon therapy for people with chronic hepatitis C led to improvement in their conditions not seen with interferon alone. However, other preliminary and double-blind trials have failed to confirm the efficacy of this approach. At the present time, sufficient evidence is lacking to support the use of this drug-nutrient combination in persons with hepatitis.
Peptides or short proteins derived from the immune organ known as the thymus gland have been investigated in combination with interferon therapy for people with hepatitis B and C. One study found that adding thymus humoral factor-gamma 2 to interferon therapy prevented decreases in white blood cell counts sometimes seen with interferon alone, and also seemed to improve the efficacy of interferon against hepatitis B. Thymus humoral factor-gamma 2 must be administered by injection, requiring consultation with a doctor. It is not known whether orally administered thymus extracts would be useful in combination with interferon.