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Glipizide: Main Image

Interactions with Vitamins


In a study of people with poorly controlled type 2 diabetes and low blood levels of magnesium, treatment with glipizide was associated with a significant rise in magnesium levels. In a randomized trial with eight healthy people, 850 mg magnesium hydroxide increased glipizide absorption and activity. In theory, such changes could be therapeutic or detrimental under varying circumstances. Therefore, people taking glipizide should consult with their doctor before taking magnesium supplements.

Interactions with Herbs

Fenugreek (Trigonella foenum-graecum)

In a randomized study of 15 patients with type 1 (insulin-dependent) diabetes, fenugreek (100 grams per day for ten days) was reported to reduce blood sugar, urinary sugar excretion, serum cholesterol, and triglycerides, with no change in insulin levels, compared with ten days of placebo. In a study of 60 people with type 2 diabetes, fenugreek (25 grams per day for 24 weeks) was reported to significantly reduce blood glucose levels. People using glipizide should talk with their doctor before making any therapy changes.

Ginkgo biloba

In a preliminary trial, administration of Ginkgo biloba who were taking oral anti-diabetes medication resulted in a significant worsening of glucose tolerance. Ginkgo did not impair glucose tolerance in individuals whose diabetes was controlled by diet. Individuals taking oral anti-diabetes medication should consult a doctor before taking Ginkgo biloba.

Gymnema sylvestre

Herbs such as Gymnema sylvestre will often improve blood-sugar control in diabetics.

Interactions with Foods & Other Compounds


Glipizide works best when taken 30 minutes before meals. Effective treatment of type 2 diabetes with glipizide includes adherence to recommended dietary guidelines.

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.

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