I have inherited Degenerative Osteoarthritis & bone spurs in both of my knees. Along with the usual medical treatments I use several different creams to give me temporary relief & enable me to moderately exercise. Topricin is by far my favorite recent purchase! I usually apply in the morning & can get relief for 1/2 a day before reapplying. If the weather is damp or rainy, I will reapply as needed. There are no permanent pain relief creams, but this one lasts for quite a while and relief is immediate upon use. Also great on bruises & achy muscles. Highly recommend!