I am typically underweight (5'10" and only 145 lbs. Sex: Male) yet mysteriously had developed a faux spare tire. According to Sandy Shaw, a co-author of Life Extension, ornithine eliminated 25 pounds of fat and created 6 pounds of muscle for her. So when I began taking it, for the first week, I actually lost weight (the fat around my stomach) which was a nuisance since I have to STRUGGLE for what other people get to enjoy for free! An actual BODY! Mine is PATHETIC! So I continued with the ornithine and weight lifting and a couple of months later, I was 170. I've tried to gain weight ALL MY LIFE by just lifting weights and eating a lot. It NEVER WORKED! Apparently, our anterior pituitary gland just stops operating after a certain age but ornithine gets it going again. Also, I'd recommend taking it an hour before you go to bed so it's completely dissolved in your bloodstream. It's like the growth hormones only start working 20 minutes after you've actually entereed first state (read:after you've fallen asleep).