My wife started taking EstroPause about six weeks ago. She took the recommended dosage of 4 gelcaps per day, approximately at mealtimes. The results became apparent about two weeks after the initial dose; her mood and vaginal moisture improved markedly. Three weeks later and she began to feel an improvement in memory, which she attributes to her daily EstroPause supplement. We don't know if this has had any effect on other aspects of her health but we are reasonably convinced that it works and have purchased a few months supply in advance. Furthermore, we have recommended it to friends and family.