I have had periods of depression and anxiety dating back to my late twenties. I have taken Paxil and some other anti-depressants. Since taking 5-HTP, I have become like the old me back in my early twenties. It has been nothing short of a miracle for me. If you suffer with depression or any mood disorder and your current medication is not doing the trick, you've got to try this. I take 3 a day and I am as level and smooth as I've ever been.