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  • Encyclopedia

Phenylalanine

Also indexed as: DLPA, DPA, LPA, D,L-Phenylalanine, L-Phenylalanine
Phenylalanine: Main Image

L-phenylalanine (LPA) serves as a building block for the various proteins that are produced in the body. LPA can be converted to L-tyrosine (another amino acid) and subsequently to L-dopa, norepinephrine, and epinephrine. LPA can also be converted (through a separate pathway) to phenylethylamine, a substance that occurs naturally in the brain and appears to elevate mood.

  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

Phenylalanine has been used in connection with the following health conditions:

Used for AmountWhy
Depression
3 to 4 grams L-phenylalanine or 150 to 200 mg of DL-phenylalanine daily2 stars[2 stars] In one study, depressed people given L-phenylalanine experienced results comparable to those produced by an antidepressant.
Low Back Pain
1,500 to 2,500 mg per day of DL-Phenylalanine2 stars[2 stars] Several studies suggest that a synthetic version of phenylalanine called D-phenylalaline, may reduce pain by decreasing the enzyme that breaks down endorphins.
Pain
1,500 mg daily2 stars[2 stars] D-phenylalanine (DPA) decreases pain by blocking the enzymes that break down the body’s natural painkillers. Clinical studies suggest DPA may inhibit some types of chronic pain.
Parkinson’s Disease
Consult a qualified healthcare practitioner2 stars[2 stars] In one trial, D-phenylalanine (DPA) supplementation improved motor control and tremors in people with Parkinson’s disease. DPA should not be taken with L-dopa as it may interfere with the transport of L-dopa to the brain.
Vitiligo
50 mg daily per 2.2 lbs (1 kg) of body weight, with ultraviolet light exposure 2 stars[2 stars] L-phenylalanine, in conjunction with ultraviolet light exposure, may improve repigmentation of skin.
Alcohol Withdrawal
(Glutamine, L-Tyrosine, Multivitamin, Tryptophan)
Refer to label instructions 1 star[1 star] In double-blind research, alcoholics treated with L-tyrosine combined with DLPA (D,L-phenylalanine), L-glutamine, prescription L-tryptophan, plus a multivitamin had reduced withdrawal symptoms and decreased stress.
Osteoarthritis
Refer to label instructions 1 star[1 star] Supplementing with D-phenylalanine (DPA) has been shown to reduce chronic pain due to OA. DPA inhibits the enzyme that breaks down some of the body’s natural painkillers.
Rheumatoid Arthritis
Refer to label instructions 1 star[1 star] D-phenylalanine has been used with mixed results to treat chronic pain, including pain caused by rheumatoid arthritis.

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.

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