Iron

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Iron

Also indexed as: Ferrous Sulfate

Iron is an essential mineral. It is part of hemoglobin, the oxygen-carrying component of the blood. Iron-deficient people tire easily in part because their bodies are starved for oxygen. Iron is also part of myoglobin, which helps muscle cells store oxygen. Without enough iron, adenosine triphosphate (ATP; the fuel the body runs on) cannot be properly synthesized. As a result, some iron-deficient people become fatigued even when their hemoglobin levels are normal (i.e., when they are not anemic).

What Are "Star" Ratings?

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Reliable and relatively consistent scientific data showing a substantial health benefit.

Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

Iron has been used in connection with the following health conditions:

Used for	Amount	Why
Anemia and Iron Deficiency	If deficient: 100 mg daily for up to one year under medical supervision	[3 stars] Taking iron may help prevent and treat anemia; ask your doctor if it’s right for you. Deficiencies of iron, vitamin B12, and folic acid are the most common nutritional causes of anemia. Learn More
Close Anemia and Iron Deficiency If deficient: 100 mg daily for up to one year under medical supervision Deficiencies of iron, vitamin B12, and folic acid are the most common nutritional causes of anemia.¹ Although rare, severe deficiencies of several other vitamins and minerals, including vitamin A,²^{, 3}vitamin B2,⁴vitamin B6,⁵^{, 6}vitamin C,⁷ and copper,⁸^{, 9} can also cause anemia by various mechanisms. Rare genetic disorders can cause anemias that may improve with large amounts of supplements such as vitamin B1.¹⁰^{, 11}
Depression and Iron Deficiency	See a doctor for evaluation	[3 stars] A lack of iron can make depression worse; check with a doctor to find out if you are iron deficient. Learn More
Close Depression and Iron Deficiency See a doctor for evaluation Iron deficiency is known to affect mood and can exacerbate depression, but it can only be diagnosed and treated by a doctor. While iron deficiency is easy to fix with iron supplements, people who have not been diagnosed with iron deficiency should not supplement iron.
Iron-Deficiency Anemia	Consult a qualified healthcare practitioner	[3 stars] Supplementing with iron is essential to treating iron deficiency. Learn More
Close Iron-Deficiency Anemia Consult a qualified healthcare practitioner Caution: People should not supplement with iron unless diagnosed with iron deficiency, because taking iron when it isn’t needed has no benefit and may be harmful. Before iron deficiency can be treated, it must be diagnosed and the cause must be found by a doctor. In addition to addressing the cause (e.g., avoiding aspirin, treating a bleeding ulcer, etc.), supplementation with iron is the primary way to resolve iron-deficiency anemia. If a doctor diagnoses iron deficiency, iron supplementation is essential. Though some doctors use higher amounts, a common daily dose for adults is 100 mg per day. Even though symptoms of deficiency should disappear much sooner, iron deficient people usually need to keep supplementing with iron for six months to one year until the ferritin test is completely normal. Even after taking enough iron to overcome the deficiency, some people with recurrent iron deficiency—particularly some premenopausal women—need to continue to supplement with smaller levels of iron, such as the 18 mg present in most multivitamin-mineral supplements. This need for continual iron supplementation even after deficiency has been overcome should be determined by a doctor. Learn More
Menorrhagia and Iron Deficiency	100 to 200 mg daily under medical supervision if deficient	[3 stars] Supplementing with iron decreases excess menstrual blood loss in iron-deficient women who have no other underlying cause for their condition. Learn More
Close Menorrhagia and Iron Deficiency 100 to 200 mg daily under medical supervision if deficient Since blood is rich in iron, excessive blood loss can lead to iron depletion. Iron deficiency can be identified with simple blood tests. If an iron deficiency is diagnosed, many doctors recommend 100–200 mg of iron per day, although recommendations vary widely. The relationship between iron deficiency and menorrhagia is complicated. Not only can the condition lead to iron deficiency, but iron deficiency can lead to or aggravate menorrhagia by reducing the capacity of the uterus to stop the bleeding. Supplementing with iron decreases excess menstrual blood loss in iron-deficient women who have no other underlying cause for their condition.¹²^{, 13} However, iron supplements should be taken only by people who have, or are at risk of developing, iron deficiency.
Athletic Performance and Iron Deficiency	Consult a qualified healthcare practitioner	[2 stars] Iron is a component of hemoglobin, which transports oxygen to muscle cells. In cases of iron deficiency, taking iron may restore levels and improve athletic performance. Learn More
Close Athletic Performance and Iron Deficiency Consult a qualified healthcare practitioner Iron is important for an athlete because it is a component of hemoglobin, which transports oxygen to muscle cells. Some athletes, especially women, do not get enough iron in their diet. In addition, for reasons that are unclear, endurance athletes, such as marathon runners, frequently have low body-iron levels.¹⁴^{, 15}^{, 16} However, anemia in athletes is often not due to iron deficiency and may be a normal adaptation to the stress of exercise.¹⁷ Supplementing with iron is usually unwise unless a deficiency has been diagnosed. People who experience undue fatigue (an early warning sign of iron deficiency) should have their iron status evaluated by a doctor. Athletes who are found to be iron deficient by a physician are typically given 100 mg per day until blood tests indicate they are no longer deficient. Supplementing iron-deficient athletes with 100 to 200 mg per day of iron increased aerobic exercise performance in some,¹⁸^{, 19}^{, 20} though not all,²¹^{, 22} double-blind studies. A recent double-blind trial found that iron-deficient women who took 20 mg per day of iron for six weeks were able to perform knee strength exercises for a longer time without muscle fatigue compared with those taking a placebo.²³
Attention Deficit–Hyperactivity Disorder and Iron Deficiency	Consult a qualified healthcare practitioner	[2 stars] In one study, iron levels were significantly lower in a group of children with ADHD than in healthy children. In the case of iron deficiency, supplementing with the mineral may improve behavior. Learn More
Close Attention Deficit–Hyperactivity Disorder and Iron Deficiency Consult a qualified healthcare practitioner Iron status, as measured by the serum ferritin concentration, was significantly lower in a group of children with ADHD than in healthy children. Ferritin levels were below normal in 84% of the children with ADHD, compared with 18% of the healthy children.²⁴ Since iron deficiency can adversely affect mood and cognitive function, iron status should be assessed in children with ADHD, and those who are deficient should receive an iron supplement. In a case report, a young boy with both ADHD and iron deficiency showed considerable improvement in behavior after receiving an iron supplement.²⁵ Iron supplementation was also beneficial in a double-blind study of children with ADHD and iron deficiency.²⁶
Breast-Feeding Support and Iron Deficiency	Consult a qualified healthcare practitioner	[2 stars] Iron may be required for infants with low iron stores or anemia. Learn More
Close Breast-Feeding Support and Iron Deficiency Consult a qualified healthcare practitioner If a doctor diagnoses iron deficiency, iron supplementation is essential. Though some doctors use higher amounts, a common daily dose for adults is 100 mg per day. Even though symptoms of deficiency should disappear much sooner, iron deficient people usually need to keep supplementing with iron for six months to one year until the ferritin test is completely normal. Even after taking enough iron to overcome the deficiency, some people with recurrent iron deficiency—particularly some premenopausal women—need to continue to supplement with smaller levels of iron, such as the 18 mg present in most multivitamin-mineral supplements. This need for continual iron supplementation even after deficiency has been overcome should be determined by a doctor.
Canker Sores and Iron Deficiency	Consult with your doctor	[2 stars] Talk to your doctor to see if your recurrent canker sores might be related to iron deficiency. Learn More
Close Canker Sores and Iron Deficiency Consult with your doctor Several preliminary studies,²⁷^{, 28}^{, 29}^{, 30} though not all,³¹ have found a surprisingly high incidence of iron and B vitamin deficiency among people with recurrent canker sores. Treating these deficiencies has been reported in preliminary³²^{, 33} and controlled³⁴ studies to reduce or eliminate canker sore recurrences in most cases. Supplementing daily with B vitamins—300 mg vitamin B1, 20 mg vitamin B2, and 150 mg vitamin B6—has been reported to provide some people with relief.³⁵ Thiamine (B1) deficiency specifically has been linked to an increased risk of canker sores.³⁶ The right supplemental level of iron requires diagnosis of an iron deficiency by a healthcare professional using lab tests.
Celiac Disease and Iron Deficiency	Consult a qualified healthcare practitioner	[2 stars] The malabsorption that occurs in celiac disease can lead to multiple nutritional deficiencies. Supplementing with iron may correct a deficiency. Learn More
Close Celiac Disease and Iron Deficiency Consult a qualified healthcare practitioner The malabsorption that occurs in celiac disease can lead to multiple nutritional deficiencies. The most common nutritional problems in people with celiac disease include deficiencies of essential fatty acids, iron, vitamin D, vitamin K, calcium, magnesium, and folic acid.³⁷Zinc malabsorption also occurs frequently in celiac disease³⁸ and may result in zinc deficiency, even in people who are otherwise in remission.³⁹ People with newly diagnosed celiac disease should be assessed for nutritional deficiencies by a doctor. Celiac patients who have not yet completely recovered should supplement with a high-potency multivitamin-mineral. Some patients may require even higher amounts of some of these vitamins and minerals—an issue that should be discussed with their healthcare practitioner. Evidence of a nutrient deficiency in a celiac patient is a clear indication for supplementation with that nutrient. After commencement of a gluten-free diet, overall nutritional status gradually improves. However, deficiencies of some nutrients may persist, even in people who are strictly avoiding gluten. For example, magnesium deficiency was found in 8 of 23 adults with celiac disease who had been following a gluten-free diet and were symptom-free. When these adults were supplemented with magnesium for two years, their bone mineral density increased significantly.⁴⁰
Night Blindness and Iron Deficiency	30 mg of iron and 6 mg of riboflavin per day	[2 stars] If a person has deficiencies of iron and riboflavin, supplementing with these nutrients may increase the benefits of vitamin A. Learn More
Close Night Blindness and Iron Deficiency 30 mg of iron and 6 mg of riboflavin per day In a study of women in Nepal, where there is a high prevalence of iron and riboflavin deficiencies, supplementation with 30 mg per day of iron and 6 mg per day of riboflavin for six weeks enhanced the effectiveness of vitamin A in the treatment of night blindness.⁴¹ It is not known whether these nutrients would be helpful for night blindness in people who are not deficient.
Pre- and Post-Surgery Health	Consult a qualified healthcare practitioner	[2 stars] Iron supplementation prior to surgery was found in one trial to reduce the need for postoperative blood transfusions. Learn More
Close Pre- and Post-Surgery Health Consult a qualified healthcare practitioner One preliminary study found iron levels to be reduced after both minor and major surgeries, and iron supplementation prior to surgery was not able to prevent this reduction.⁴² A controlled trial found that intravenous iron was more effective than oral iron for restoring normal iron levels after spinal surgery in children.⁴³ One animal study reported that supplementation with fructo-oligosaccharides (FOS) improved the absorption of iron and prevented anemia after surgery,⁴⁴ but no human trials have been done to confirm this finding. Some researchers speculate that iron deficiency after a trauma such as surgery is an important mechanism for avoiding infection, and they suggest that iron supplements should not be given after surgery.⁴⁵ Patients who have undergone major surgery frequently need blood transfusions to replace blood lost during the procedure. Studies have found that 18 to 21% of surgery patients were anemic prior to surgery,⁴⁶^{, 47} and these anemic patients required more blood after surgery than did non-anemic surgery patients. Supplementation with iron prior to surgery was found in a controlled trial to reduce the need for blood transfusions, whether or not iron deficiency was present.⁴⁸Iron supplements (99 mg per day) given before and for two months after joint surgery in another controlled trial improved blood values but did not change the length of hospitalization or the risk of post-operative fever.⁴⁹ Pre-operative iron supplementation in combination with a medication that stimulates red blood cell production in the bone marrow is considered by some doctors to be an effective way to minimize the need for post-operative blood transfusions.⁵⁰ Learn More
Pregnancy and Postpartum Support	Consult a qualified healthcare practitioner	[2 stars] Iron requirements increase during pregnancy, making iron deficiency in pregnancy quite common. Supplementation may help prevent a deficiency. Learn More
Close Pregnancy and Postpartum Support Consult a qualified healthcare practitioner Iron requirements increase during pregnancy, making iron deficiency in pregnancy quite common.⁵¹ Iron supplement use in the United States is estimated at 85% during pregnancy, with most women taking supplements three or more times per week for three months.⁵² Pregnant women with a documented iron deficiency need doctor-supervised treatment. In one study, 65% of women who were not given extra iron developed iron deficiency during pregnancy, compared with none who received an iron supplement.⁵³ However, there is a clear increase in reported side effects with increasing supplement amounts of iron, especially iron sulfate.⁵⁴^{, 55} Supplementation with large amounts of iron has also been shown to reduce blood levels of zinc.⁵⁶ Although the significance of that finding is not clear, low blood levels of zinc have been associated with an increased risk of complications in both the mother and fetus.⁵⁷ Iron supplementation was associated in one study with an increased incidence of birth defects,⁵⁸ possibly as a result of an iron-induced deficiency of zinc. Although additional research needs to be done, the evidence suggests that women who are supplementing with iron during pregnancy should also take a multivitamin-mineral formula that contains adequate amounts of zinc. To be on the safe side, pregnant women should discuss their supplement program with a doctor. Learn More
Restless Legs Syndrome and Iron Deficiency	Consult a qualified healthcare practitioner	[2 stars] When iron deficiency is the cause of restless leg syndrome, supplementing with iron may reduce the severity of the symptoms. Learn More
Close Restless Legs Syndrome and Iron Deficiency Consult a qualified healthcare practitioner Mild iron deficiency is common, even in people who are not anemic. When iron deficiency is the cause of RLS, supplementation with iron has been reported to reduce the severity of the symptoms. In one trial, 74 mg of iron taken three times a day for two months, reduced symptoms in people with RLS.⁵⁹ In people who are not deficient in iron, iron supplementation has been reported to not help reduce symptoms of RLS.⁶⁰ Most people are not iron deficient, and taking too much can lead to adverse effects. Therefore, iron supplements should only be taken by people who have a diagnosed deficiency.
Alzheimer’s Disease (Coenzyme Q10, Vitamin B6)	Refer to label instructions	[1 star] A combination of coenzyme Q10, iron (sodium ferrous citrate), and vitamin B6 may improve mental status in people with Alzheimer’s disease. Learn More
Close Alzheimer’s Disease In a preliminary report, two people with a hereditary form of Alzheimer’s disease received daily: coenzyme Q10 (60 mg), iron (150 mg of sodium ferrous citrate), and vitamin B6 (180 mg). Mental status improved in both patients, and one became almost normal after six months.⁶¹ Learn More
Dermatitis Herpetiformis and Iron Deficiency	Refer to label instructions	[1 star] Talk to your doctor to see if supplementing with iron can counteract the nutrient deficiency that often occurs as a result of malabsorption. Learn More
Close Dermatitis Herpetiformis and Iron Deficiency People with DH frequently have mild malabsorption (difficulty absorbing certain nutrients) associated with low stomach acid (hypochlorhydria) and inflammation of the stomach lining (atrophic gastritis).⁶² Mild malabsorption may result in anemia⁶³ and nutritional deficiencies of iron, folic acid,⁶⁴^{, 65}vitamin B12,⁶⁶^{, 67} and zinc.⁶⁸^{, 69}^{, 70} More severe malabsorption may result in loss of bone mass.⁷¹ Additional subtle deficiencies of vitamins and minerals are possible, but have not been investigated. Therefore, some doctors recommend people with DH have their nutritional status checked regularly with laboratory studies. These doctors may also recommend multivitamin-mineral supplements and, to correct the low stomach acid, supplemental betaine HCl (a source of hydrochloric acid).
Female Infertility and Iron Deficiency	Refer to label instructions	[1 star] Even subtle iron deficiencies have been tentatively linked to infertility. Women who are infertile should consult a doctor to rule out the possibility of iron deficiency Learn More
Close Female Infertility and Iron Deficiency In preliminary research, even a subtle deficiency of iron has been tentatively linked to infertility.⁷² Women who are infertile should consult a doctor to rule out the possibility of iron deficiency.
HIV and AIDS Support	Refer to label instructions	[1 star] Iron deficiency is often present in HIV-positive children. Supplementing with it, under a doctor's supervision, may support immune function. Learn More
Close HIV and AIDS Support Iron deficiency is often present in HIV-positive children.⁷³ While iron is necessary for normal immune function, iron deficiency also appears to protect against certain bacterial infections.⁷⁴ Iron supplementation could therefore increase the severity of bacterial infections in people with AIDS. For that reason, people with HIV infection or AIDS should consult a doctor before supplementing with iron. Learn More

References

1. Little DR. Ambulatory management of common forms of anemia. Am Fam Physician 1999;59:1598–604 [review].

2. Hodges RE, Sauberlich HE, Canham JE, et al. Hematopoietic studies in vitamin A deficiency. Am J Clin Nutr 1978;31:876–85 [review].

3. Bloem MW. Interdependence of vitamin A and iron: an important association for programmes of anaemia control. Proc Nutr Soc 1995;54:501–8 [review].

4. Lane M, Alfrey CP. The anemia of human riboflavin deficiency. Blood 1965;25:432–42.

5. Orehek AJ, Kollas CD. Refractory postpartum anemia due to vitamin B6 deficiency. Ann Intern Med 1997;126(10):834–5 [letter].

6. Iwama H, Iwase O, Hayashi S, et al. Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency. Rinsho Ketsueki 1998;39:1127–30 [in Japanese].

7. Hirschmann JV, Raugi GJ. Adult scurvy. J Am Acad Dermatol 1999;41:895–906 [review].

8. Summerfield AL, Steinberg FU, Gonzalez JG. Morphologic findings in bone marrow precursor cells in zinc-induced copper deficiency anemia. Am J Clin Pathol 1992;97:665–8.

9. Freycon F, Pouyau G. Rare nutritional deficiency anemia: deficiency of copper and vitamin E. Sem Hop 1983;59:488–93 [review] [in French].

10. Borgna-Pignatti C, Marradi P, Pinelli L, et al. Thiamine-responsive anemia in DIDMOAD syndrome. J Pediatr 1989;114:405–10.

11. Neufeld EJ, Mandel H, Raz T, et al. Localization of the gene for thiamine-responsive megaloblastic anemia syndrome, on the long arm of chromosome 1, by homozygosity mapping. Am J Hum Genet 1997;61:1335–41.

12. Samuels, AJ. Studies in patients with functional menorrhagia: the antimenorrhagic effect of the adequate replication of iron stores. Isr J Med Sci 1965;1:851–3.

13. Taymor ML, Sturgis SH, Yahia C. The etiological role of chronic iron deficiency in production of menorrhagia. JAMA 1964;187:323–7.

14. Mechrefe A, Wexler B, Feller E. Sports anemia and gastrointestinal bleeding in endurance athletes. Med Health R I 1997;80:216–8.

15. Clarkson PM. Micronutrients and exercise: anti-oxidants and minerals. J Sports Sci 1995;13:S11–24 [review].

16. Smith JA. Exercise, training and red blood cell turnover. Sports Med 1995;19:9–31.

17. Smith JA. Exercise, training and red blood cell turnover. Sports Med 1995;19:9–31 [review].

18. Brownlie T 4th, Utermohlen V, Hinton PS, et al. Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women. Am J Clin Nutr 2002;75:734–42.

19. Friedmann B, Weller E, Mairbaurl H, Bartsch P. Effects of iron repletion on blood volume and performance capacity in young athletes. Med Sci Sports Exerc 2001;33:741–6.

20. Hinton PS, Giordano C, Brownlie T, Haas JD. Iron supplementation improves endurance after training in iron-depleted, nonanemic women. J Appl Physiol 2000;88:1103–11.

21. Zhu YI, Haas JD. Altered metabolic response of iron-depleted nonanemic women during a 15-km time trial. J Appl Physiol 1998;84:1768–75.

22. Nielsen P, Nachtigall D. Iron supplementation in athletes. Current recommendations. Sports Med 1998;26:207–16 [review].

23. Brutsaert TD, Hernandez-Cordero S, Rivera J, et al. Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women. Am J Clin Nutr 2003;77:441–8.

24. Konofal E, Lecendreux M, Arnulf I, Mouren MC. Iron deficiency in children with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med 2004;158:1113–5.

25. Konofal E, Lecendreux M, Deron J, et al. Effects of iron supplementation on attention defecit hyperactivity disorder in children. Pediatr Neurol 2008; 38:20-6.

26. Konofal E, Lecendreux M, Deron J, et al. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol 2008;38:20–6.

27. Porter SR, Scully C, Flint S. Hematologic status in recurrent aphthous stomatitis compared to other oral disease. Oral Surg Oral Med Oral Pathol 1988;66:41–4.

28. Palopoli J, Waxman J. Recurrent aphthous stomatitis and vitamin B12 deficiency. South Med J 1990;83:475–7.

29. Wray D, Ferguson MM, Hutcheon WA, Dagg JH. Nutritional deficiencies in recurrent aphthae. J Oral Pathol 1978;7:418–23.

30. Barnadas MA, Remacha A, Condomines J, de Moragas JM. [Hematologic deficiencies in patients with recurrent oral aphthae]. Med Clin (Barc) 1997;109:85–7 [in Spanish].

31. Olson JA, Feinberg I, Silverman S, et al. Serum vitamin B12, folate, and iron levels in recurrent aphthous ulceration. Oral Surg Oral Med Oral Pathol 1982;54:517–20.

32. Weusten BL, van de Wiel A. Aphthous ulcers and vitamin B12 deficiency. Neth J Med 1998;53:172–5.

33. Porter S, Flint S, Scully C, Keith O. Recurrent aphthous stomatitis: the efficacy of replacement therapy in patients with underlying hematinic deficiencies. Ann Dent 1992;51:14–6.

34. Wray D, Ferguson MM, Mason DK, et al. Recurrent aphthae: treatment with vitamin B12, folic acid, and iron. Br Med J 1975;2(5969):490–3.

35. Nolan A, McIntosh WB, Allam BF, Lamey PJ. Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. J Oral Pathol Med 1991;20:389–91.

36. Haisraeli-Shalish M, Livneh A, Katz J, et al. Recurrent aphthous stomatitis and thiamine deficiency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:634–6.

37. Connon JJ. Celiac disease. In: Shils ME, Olson JA, Shike M, eds. Modern Nutrition in Health and Disease, 8th ed. Philadelphia: Lea & Febiger, 1994, 1062.

38. Crofton RW, Glover SC, Ewen SWB, et al. Zinc absorption in celiac disease and dermatitis herpetiformis: a test of small intestinal function. Am J Clin Nutr 1983;38:706–12.

39. Solomons NW, Rosenberg IH, Sandstead HH. Zinc nutrition in celiac sprue. Am J Clin Nutr 1976;29:371–5.

40. Rude RK, Olerich M. Magnesium deficiency: possible role in osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int 1996;6:453–61.

41. Graham JM, Haskell MJ, Pandey P, et al. Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, nightblind Nepali women. Am J Clin Nutr 2007;85:1375–84.

42. van Iperen CE, Kraaijenhagen RJ, Biesma DH, et al. Iron metabolism and erythropoiesis after surgery. Br J Surg 1998;85:41–5.

43. Berniere J, Dehullu JP, Gall O, Murat I. Intravenous iron in the treatment of postoperative anemia in surgery of the spine in infants and adolescents. Rev Chir Orthop Reparatrice Appar Mot 1998;84:319–22 [in French].

44. Ohta A, Ohtsuki M, Uehara M, et al. Dietary fructo-oligosaccharides prevent postgastrectomy anemia and osteopenia in rats. J Nutr 1998;128:485–90.

45. Mainous MR, Deitch EA. Nutrition and infection. Surg Clin North Am 1994;74:659–76 [review].

46. Andrews CM, Lane DW, Bradley JG. Iron pre-load for major joint replacement. Transfus Med 1997;7:281–6.

47. Goodnough LT, Vizmeg K, Sobecks R, et al. Prevalence and classification of anemia in elective orthopedic surgery patients: implications for blood conservation programs. Vox Sang 1992;63:90–5.

48. Andrews CM, Lane DW, Bradley JG. Iron pre-load for major joint replacement. Transfus Med 1997;7:281–6.

49. Guinea JM, Lafuente P, Mendizabal A, et al. Results of preoperative autotransfusion with ferrous ascorbate prophylaxis in orthopedic surgery patients. Sangre (Barc) 1996;41:25–8 [in Spanish].

50. Tasaki T, Ohto H, Motoki R. Pharmacological approaches to reduce perioperative transfusion requirements in the aged. Drugs Aging 1995;6:91–104 [review].

51. Allen LH. Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr 2000;71(5 Suppl):1280S–4S [review].

52. Yu SM, Keppel KG, Singh GK, Kessel W. Preconceptional and prenatal multivitamin-mineral supplement use in the 1988 National Maternal and Infant Health Survey. Am J Public Health 1996;86:240–2.

53. Romslo I, Haram K, Sagen N, Augensen K. Iron requirement in normal pregnancy as assessed by serum ferritin, serum transferrin saturation and erythrocyte protoporphyrin determinations. Br J Obstet Gynaecol 1983;90:101–7.

54. Hemminki E, Uski A, Koponen P, Rimpela U. Iron supplementation during pregnancy—experiences of a randomized trial relying on health service personnel. Control Clin Trials 1989;10:290–8.

55. al-Momen AK, al-Meshari A, al-Nuaim L, et al. Intravenous iron sucrose complex in the treatment of iron deficiency anemia during pregnancy. Eur J Obstet Gynecol Reprod Biol 1996;69:121–4.

56. Bloxam DL, Williams NR, Waskett RJD, et al. Maternal zinc during oral iron supplementation in pregnancy: a preliminary study. Clin Sci 1989;76:59–65.

57. Mukherjee MD, Sandstead HH, Ratnaparkhi MV, et al. Maternal zinc, iron, folic acid, and protein nutriture and outcome of human pregnancy. Am J Clin Nutr 1984;40:496–507.

58. Nelson MM, Forfar JO. Associations between drugs administered during pregnancy and congenital abnormalities of the fetus. Br Med J 1971;1:523–7.

59. O’Keeffe ST, Gavin K, Lavan JN. Iron status and restless legs syndrome in the elderly. Age Ageing 1994;23:200–3.

60. Davis BJ, Rajput A, Rajput ML, et al. A randomized, double-blind placebo-controlled trial of iron in restless legs syndrome. Eur Neurol 2000;43:70–5.

61. Imagawa M, Naruse S, Tsuji S, et al. Coenzyme Q10, iron, and vitamin B6 in genetically-confirmed Alzheimer’s disease. Lancet 1992;340:671 [letter].

62. Yancy KB, Lawley TJ. “Immunologically Mediated Skin Diseases.”Harrison’s Online. 1999. https://www.harrisonsonline.com/hill-bin/Chapters.cgi (Jan 10, 2000).

63. Kastrup W, Mobacken H, Stockbrugger R, et al. Malabsorption of vitamin B12 in dermatitis herpetiformis and its association with pernicious anaemia. Acta Med Scand 1986;220:261–8.

64. Gawkrodger DJ, Ferguson A, Barnetson RS. Nutritional status in patients with dermatitis herpetiformis. Am J Clin Nutr 1988;48:355–60.

65. Hoffbrand AV, Douglas AP, Fry L, Stewart JS. Malabsorption of dietary folate (Pteroylpolyglutamates) in adult coeliac disease and dermatitis herpetiformis. Br Med J 1970;4:85–9.

66. Davies MG, Marks R, Nuki G. Dermatitis herpetiformis—a skin manifestation of a generalized disturbance in immunity. Q J Med 1978;47:221–48.

67. Kastrup W, Mobacken H, Stockbrugger R, et al. Malabsorption of vitamin B12 in dermatitis herpetiformis and its association with pernicious anaemia. Acta Med Scand 1986;220:261–8.

68. Crofton RW, Glover SC, Ewen SW, et al. Zinc absorption in celiac disease and dermatitis herpetiformis: a test of small intestinal function. Am J Clin Nutr 1983;38:706–12.

69. Gawkrodger DJ, Ferguson A, Barnetson RS. Nutritional status in patients with dermatitis herpetiformis. Am J Clin Nutr 1988;48:355–60.

70. Hoffbrand AV, Douglas AP, Fry L, Stewart JS. Malabsorption of dietary folate (Pteroylpolyglutamates) in adult coeliac disease and dermatitis herpetiformis. Br Med J 1970;4:85–9.

71. Di Stefano M, Jorizzo RA, Veneto G, et al. Bone mass and metabolism in dermatitis herpetiformis. Dig Dis Sci 1999;44:2139–43.

72. Rushton DH, Ramsay ID, Gilkes JJH, Norris MJ. Ferritin and fertility. Lancet 1991;337:1554 [letter].

73. Castaldo A, Tarallo L, Palomba E, et al. Iron deficiency and intestinal malabsorption in HIV disease. J Pediatr Gastroenterol Nutr 1996;22:359–63.

74. Humbert JR, Moore LL. Iron deficiency and infection: a dilemma. J Pediatr Gastroenterol Nutr 1983;2:403–6.

75. Sullivan JL. Stored iron and ischemic heart disease. Circulation 1992;86:1036 [editorial].

76. Pollitt E. Poverty and child development: relevance of research in developing countries to the United States. Child Dev 1994;65(2 Spec No):283–95.

77. Hurtado EK, Claussen AH, Scott KG. Early childhood anemia and mild or moderate mental retardation. Am J Clin Nutr 1999;69:115–9.

78. Roncagliolo M, Garrido M, Walter T, et al. Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: delayed maturation of auditory brainstem responses. Am J Clin Nutr 1998;68:683–90.

79. Williams J, Wolff A, Daly A, et al. Iron supplemented formula milk related to reduction in psychomotor decline in infants from inner city areas: randomised study. BMJ 1999;318:693–7

80. Morley R, Abbott R, Fairweather-Tait S, et al. Iron fortified follow on formula from 9 to 18 months improves iron status but not development or growth: a randomised trial. Arch Dis Child 1999;81:247–52.

81. Bridge EM, Livingston S, Tietze C. Breath-holding spells: their relationship to syncope, convulsions and other phenomena. J Pediatr 1943;23:539–61.

82. Holowach J, Thurston DL. Breath-holding spells and anemia. N Engl J Med 1963;268:21–3.

83. Bhatia MS, Singhal PK, Dhar NK, et al. Breath holding spells: an analysis of 50 cases. Indian Pediatr 1990;27:1073–9.

84. Colina KF, Abelson HT. Resolution of breath-holding spells with treatment of concomitant anemia. J Pediatr 1995;126:395–7.

85. Daoud AS, Batieha A, al-Sheyyab M, et al. Effectiveness of iron therapy on breath-holding spells. J Pediatr 1997;130:547–50.

86. Mocan H, Yildiran A, Orhan F, Erduran E. Breath holding spells in 91 children and response to treatment with iron. Arch Dis Child 1999;81:261–2.

87. Dietzfelbinger H. Bioavailability of bi- and trivalent oral iron preparations. Investigations of iron absorption by postabsorption serum iron concentrations curves. Arzneimittelforschung 1987;37:107–12 [review].

88. Davidsson L, Kastenmayer P, Szajewska H, et al. Iron bioavailability in infants from an infant cereal fortified with ferric pyrophosphate or ferrous fumarate.Am J Clin Nutr 2000;71:1597–602.

89. Hansen CM. Oral iron supplements. Am Pharm 1994 Mar;NS34:66–71 [review].

90. Simmons WK, Cook JD, Bingham KC, et al. Evaluation of a gastric delivery system for iron supplementation in pregnancy. Am J Clin Nutr 1993;58:622–6.

91. Ricketts CD. Iron bioavailability from controlled-release and conventional iron supplements. J Appl Nutr 1993;45:13–19.

92. Rudinskas L, Paton TW, Walker SE. Poor clinical response to enteric-coated iron preparations. Can Med Assoc J 1989;141:565–6.

93. Walker SE, Paton TW, Cowan DH, et al. Bioavailability of iron in oral ferrous sulfate preparations in healthy volunteers. Can Med Assoc J 1989;141:543–7.

94. Bender-Gotze C. Therapy of juvenile iron deficiency with bivalent iron dragees (Fe2-fumarate, succinate, sulfate). Controlled double-blind study. Fortschr Med 1980;98:590–3 [in German].

95. Hurrell RF, Furniss DE, Burri J, et al. Iron fortification of infant cereals: a proposal for the use of ferrous fumarate or ferrous succinate. Am J Clin Nutr 1989;49:1274–82.

96. Casparis D, Del Carlo P, Branconi F, et al. Effectiveness and tolerability of oral liquid ferrous gluconate in iron-deficiency anemia in pregnancy and in the immediate post-partum period: comparison with other liquid or solid formulations containing bivalent or trivalent iron. Minerva Ginecol 1996;48:511–8 [in Italian].

97. Frykman E, Bystrom M, Jansson U, et al. Side effects of iron supplements in blood donors: superior tolerance of heme iron. J Lab Clin Med 1994;123:561–4.

98. Martinez C, Fox T, Eagles J, Fairweather-Tait S. Evaluation of iron bioavailability in infant weaning foods fortified with haem concentrate. J Pediatr Gastroenterol Nutr 1998;27:419–24.

99. Hertrampf E, Olivares M, Pizarro F, et al. Haemoglobin fortified cereal: a source of available iron to breast-fed infants. Eur J Clin Nutr. 1990;44:793–8.

100. Calvo E, Hertrampf E, de Pablo S, et al. Haemoglobin-fortified cereal: an alternative weaning food with high iron bioavailability. Eur J Clin Nutr 1989;43:237–43 [review].

101. Fox TE, Eagles J, Fairweather-Tait SJ. Bioavailability of iron glycine as a fortificant in infant foods. Am J Clin Nutr 1998;67:664–8.

102. Pineda O, Ashmead HD, Perez JM, Lemus C. Effectiveness of iron amino acid chelate on the treatment of iron deficiency anemia in adolescents. J Appl Nutr 1994;46:2–13.

103. Hallberg L, Hulthen L. Prediction of dietary iron absorption: an algorithm for calculating absorption and bioavailability of dietary iron. Am J Clin Nutr 2000;71:1147–60.

104. Disler PB, Lynch SR, Charlton RW, et al. The effect of tea on iron absorption. Gut 1975;16:193–200.

105. Derman D, Sayers M, Lynch SR, et al. Iron absorption from a cereal-based meal containing cane sugar fortified with ascorbic acid. Br J Nutr 1977;38:261–9.

106. Hallberg L, Rossander L. Effect of different drinks on the absorption of non-heme iron from composite meals. Hum Nutr Appl Nutr 1982;36:116–23.

107. Kaltwasser JP, Werner E, Schalk K, et al. Clinical trial on the effect of regular tea drinking on iron accumulation in genetic haemochromatosis. Gut 1998;43:699–704.

108. Samman S, Sandstrom B, Toft MB, et al. Green tea or rosemary extract added to foods reduces nonheme-iron absorption. Am J Clin Nutr 2001;73:607–12.

109. Derman D, Sayers M, Lynch SR, et al. Iron absorption from a cereal-based meal containing cane sugar fortified with ascorbic acid. Br J Nutr 1977;38:261–9.

110. Hallberg L, Rossander L. Effect of different drinks on the absorption of non-heme iron from composite meals. Hum Nutr Appl Nutr 1982;36:116–23.

111. Morck TA, Lynch SR, Cook JD. Inhibition of food iron absorption by coffee. Am J Clin Nutr 1983;37:416–20.

112. Bezwoda WR, Torrance JD, Bothwell TH, et al. Iron absorption from red and white wines. Scand J Haematol 1985;34:121–7.

113. Cook JD, Reddy MB, Hurrell RF. The effect of red and white wines on nonheme-iron absorption in humans. Am J Clin Nutr 1995;61:800–4.

114. Hallberg L, Hulthen L. Prediction of dietary iron absorption: an algorithm for calculating absorption and bioavailability of dietary iron. Am J Clin Nutr 2000;71:1147–60.

115. Sandberg AS, Brune M, Carlsson NG, et al. Inositol phosphates with different numbers of phosphate groups influence iron absorption in humans. Am J Clin Nutr 1999;70:240–6.

116. Hallberg L, Brune M, Rossander L. Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate. Am J Clin Nutr 1989;49:140–4.

117. Simpson KM, Morris ER, Cook JD. The inhibitory effect of bran on iron absorption. Am J Clin Nutr 1981;34:1469–78.

118. Hallberg L, Brune M, Erlandsson M, et al. Calcium: effect of different amounts on nonheme- and heme-iron absorption in humans. Am J Clin Nutr 1991;53:112–9.

119. Hallberg L, Rossander-Hulthén L, Brune M, Gleerup A. Inhibition of haem-iron absorption in man by calcium. Br J Nutr 1992;69:533–40.

120. Cook JD, Morck TA, Lynch SR. The inhibitory effect of soy products on nonheme iron absorption in man. Am J Clin Nutr 1981;34:2622–9.

121. Hallberg L, Rossander L. Effect of soy protein on nonheme iron absorption in man. Am J Clin Nutr 1982;36:514–20.

122. Cook JD, Monsen ER. Food iron absorption in human subjects. III. Comparison of the effect of animal proteins on nonheme iron absorption. Am J Clin Nutr 1976;29:859–67.

123. Rossander L, Hallberg L, Bjorn-Rasmussen E. Absorption of iron from breakfast meals. Am J Clin Nutr 1979;32:2484–9.

124. Hallberg L. Bioavailability of dietary iron in man. Annu Rev Nutr 1981;1:123–47 [review].

125. Layrisse M, Martinez-Torres C, Roche M. Effect of interaction of various foods on iron absorption. Am J Clin Nutr 1968;21:1175–83.

126. Cook JD, Monsen ER. Food iron absorption in human subjects. III. Comparison of the effect of animal proteins on nonheme iron absorption. Am J Clin Nutr 1976;29:859–67.

127. Bjorn-Rasmussen E, Hallberg L. Effect of animal proteins on the absorption of food iron in man. Nutr Metab 1979;23:192–202.

128. Hallberg L, Rossander L. Improvement of iron nutrition in developing countries: comparison of adding meat, soy protein, ascorbic acid, citric acid, and ferrous sulphate on iron absorption from a simple Latin American-type of meal. Am J Clin Nutr 1984;39:577–83.

129. Hunt JR, Gallagher SK, Johnson LK. Effect of ascorbic acid on apparent iron absorption by women with low iron stores. Am J Clin Nutr 1994;59:1381–5.

130. Hallberg L, Brune M, Rossander L. The role of vitamin C in iron absorption. Int J Vitam Nutr Res Suppl 1989;30:103–8.

131. Lynch SR, Cook JD. Interaction of vitamin C and iron. Ann N Y Acad Sci 1980;355:32–44.

132. Hallberg L, Brune M, Rossander L. Effect of ascorbic acid on iron absorption from different types of meals. Studies with ascorbic-acid-rich foods and synthetic ascorbic acid given in different amounts with different meals. Hum Nutr Appl Nutr 1986;40:97–113.

133. Hunt JR, Gallagher SK, Johnson LK. Effect of ascorbic acid on apparent iron absorption by women with low iron stores. Am J Clin Nutr 1994;59:1381–5.

134. Suharno D, West CE, Muhilal, et al. Supplementation with vitamin A and iron for nutritional anemia in pregnant women in West Java, Indonesia. Lancet 1993;342:1325–8.

135. Semba RD, Muhilal, West KP Jr, et al. Impact of vitamin A supplementation on hematological indicators of iron metabolism and protein status in children. Nutr Res 1992;12:469–78.

136. Macfarlane BJ, van der Riet WB, Bothwell TH, et al. Effect of traditional oriental soy products on iron absorption. Am J Clin Nutr 1990;51:873–80.

137. Baynes RD, Macfarlane BJ, Bothwell TH, et al. The promotive effect of soy sauce on iron absorption in human subjects. Eur J Clin Nutr 1990;44:419–24.

138. Charlton RW, Jacobs P, Seftel H, Bothwell TH. Effect of alcohol on iron absorption. Br Med J 1964;5422:1427–9.

139. Hallberg L, Rossander L. Effect of different drinks on the absorption of non-heme iron from composite meals. Hum Nutr Appl Nutr 1982;36:116–23.

140. Finley JW. Manganese absorption and retention by young women is associated with serum ferritin concentration. Am J Clin Nutr 1999;70:37–43.

141. Davis CD, Malecki EA, Gerger JL. Interactions among dietary manganese, heme iron, and nonheme iron in women. Am J Clin Nutr 1992;56:926–32.

142. FDA Medical Bulletin, U.S. Government Printing Office, document number 386–942/00002; February 6, 1995.

143. Nightingale SL. Action to prevent accidental iron poisoning in children. JAMA 1997;27:1343.

144. Krezenlok EP, Hoff JV. Accidental iron poisoning. A problem of marketing and labeling. Pediatrics 1979;63:591–6.

145. Morris CC. Pediatric iron poisonings in the United States. South Med J 2000;93:352–8.

146. Mills KC, Curry SC. Acute iron poisoning. Emerg Med Clin N Am 1994;12;397–413.

147. Cutler P. Deferoxamine therapy in high-ferritin diabetes. Diabetes 1989;38:1207–10.

148. Stevens RG, Graubard BI, Micozzi MS, et al. Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int J Cancer 1994;56:364–9.

149. Weinberg ED. Iron withholding: a defense against infection and neoplasia. Am J Physiol 1984;64:65–102.

150. Oh VMS. Iron dextran and systemic lupus erythematosus. Br Med J 1992;305:1000 [letter].

151. Dabbagh AJ, Trenam CW, Morris CJ, Blake DR. Iron in joint inflammation. Ann Rheum Dis 1993;52:67–73.

152. Bartzokis G, Cummings J, Perlman S, et al. Increased basal ganglia iron levels in Huntington disease. Arch Neurol 1999;56:569–74.

153. Salonen JT, Nyyssonen K, Korpela H, et al. High stored iron levels associated with excess risk of myocardial infarction in western Finnish men. Circulation 1992;86:803–11.

154. Kechl S, Willeit J, Egger G, et al. Body iron stores and the risk of carotid atherosclerosis. Circulation 1997;96:3300–7.

155. Tzonou A, Lagiou P, Trichopoulou A, et al. Dietary iron and coronary heart disease risk: a study from Greece. Am J Epidemiol 1998;147:161–6.

156. Danesh J, Appleby P. Coronary heart disease and iron status. Meta-analyses of prospective studies. Circulation 1999;99:852–4.

157. de Valk B, Marx MMJ. Iron, atherosclerosis, and ischemic heart disease. Arch Intern Med 1999;159:1542–8 [review].

158. Klipstein-Grobusch K, Koster JF, Grobbee DE, et al. Serum ferritin and risk of myocardial infarction in the elderly: the Rotterdam Study. Am J Clin Nutr 1999;69:1231–6.

159. Roob JM, Khoschsorur G, Tiran A, et al. Vitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis. J Am Soc Nephrol 2000;11:539–49.

160. Muñoz EC, Rosado JL, Lopez P, et al. Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers. Am J Clin Nutr 2000;71:789–94.

161. Di Bisceglie AM, Bonkovsky HL, Chopra S, et al. Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: a multicenter, prospective, randomized, controlled trial. Hepatology 2000;32:135–8.

162. Ferrennini E. Insulin resistance, iron, and the liver. Lancet 2000;355:2181–2 [letter].

Encyclopedia

Related Topics

Iron has been used in connection with the following health conditions:

Anemia and Iron Deficiency

Depression and Iron Deficiency

Iron-Deficiency Anemia

Menorrhagia and Iron Deficiency

Athletic Performance and Iron Deficiency

Attention Deficit–Hyperactivity Disorder and Iron Deficiency

Breast-Feeding Support and Iron Deficiency

Canker Sores and Iron Deficiency

Celiac Disease and Iron Deficiency

Night Blindness and Iron Deficiency

Pre- and Post-Surgery Health

Pregnancy and Postpartum Support

Restless Legs Syndrome and Iron Deficiency

Alzheimer’s Disease

Dermatitis Herpetiformis and Iron Deficiency

Female Infertility and Iron Deficiency

HIV and AIDS Support

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Encyclopedia

Iron

Related Topics

Iron has been used in connection with the following health conditions:

Anemia and Iron Deficiency

Depression and Iron Deficiency

Iron-Deficiency Anemia

Menorrhagia and Iron Deficiency

Athletic Performance and Iron Deficiency

Attention Deficit–Hyperactivity Disorder and Iron Deficiency

Breast-Feeding Support and Iron Deficiency

Canker Sores and Iron Deficiency

Celiac Disease and Iron Deficiency

Night Blindness and Iron Deficiency

Pre- and Post-Surgery Health

Pregnancy and Postpartum Support

Restless Legs Syndrome and Iron Deficiency

Alzheimer’s Disease

Dermatitis Herpetiformis and Iron Deficiency

Female Infertility and Iron Deficiency

HIV and AIDS Support