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St. John’s Wort

Also indexed as: Hypericum, Hypericum perforatum, Klamath Weed, Saint John's wort
St. John’s Wort: Main Image© Steven Foster
Common names:
Hypericum, Klamath Weed
Botanical names:
Hypericum perforatum

Interactions with Supplements, Foods, & Other Compounds

Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market. Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort.

Interactions with Medicines

Certain medicines interact with this supplement.

May Be Beneficial:Some medicines may increase the need for this supplement.
Avoid:Some medicines interact with this supplement, so they should not be taken together.
Check: Some interactions between this supplement and certain medicines require more explanation. Click the link to see details.

Note: The following list only includes the generic or class name of a medicine. To find a specific brand name, use the Medicines Index.

Avoid:Alprazolam
Avoid:Amitriptyline
Avoid:Amoxapine
Avoid:Atazanavir
Avoid:Atorvastatin
Avoid:Chlordiazepoxide
Avoid:Clomipramine
Avoid:Clonazepam
Avoid:Cyclosporine
Avoid:Desipramine
Avoid:Desogestrel-Ethinyl Estradiol
Avoid:Diazepam
Avoid:Digoxin
Avoid:Doxepin
Avoid:Estazolam
Avoid:Ethinyl Estradiol and Levonorgestrel
Avoid:Ethinyl Estradiol and Norethindrone
Avoid:Ethinyl Estradiol and Norgestimate
Avoid:Ethinyl Estradiol and Norgestrel
Avoid:Fluoxetine
Avoid:Fluvastatin
Avoid:Fluvoxamine
Avoid:Fosamprenavir
Avoid:Imipramine
Avoid:Indinavir
Avoid:Levonorgestrel
Avoid:Levonorgestrel-Ethinyl Estrad
Avoid:Lorazepam
Avoid:Lovastatin
Avoid:Mestranol and Norethindrone
Avoid:Nefazodone
Avoid:Norgestimate-Ethinyl Estradiol
Avoid:Nortriptyline
Avoid:Omeprazole
Avoid:Paroxetine
Avoid:Phenelzine
Avoid:Pravastatin
Avoid:Protriptyline
Avoid:Rosuvastatin
Avoid:Sertraline
Avoid:Simvastatin
Avoid:Simvastatin
Avoid:Temazepam
Avoid:Theophylline
Avoid:Trazodone
Avoid:Trimipramine
Avoid:Venlafaxine
Avoid:Warfarin
Check: Fexofenadine


St Johns Wort Benefits
Here is what people are saying about the benefits of St Johns Wort.
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Copyright © 2011 Aisle7.

Learn more about Aisle7, the company.

Learn more about the authors of Aisle7 products.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.

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Statements made about specific vitamins, supplements, procedures or other items sold on or through this website have not been evaluated by eVitamins, the Australian Therapeutic Goods Administration (TGA) or the United States Food and Drug Administration. They are not intended to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only. As always, please consult with a licensed doctor or physician before starting any diet, exercise or supplement program, before taking any vitamin or medication, or if you have or suspect you might have a problem.

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