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Age-Related Cognitive Decline

Also indexed as: Age-Associated Memory Impairment, Age-Consistent Memory Decline, ARCD, Benign Senescent Forgetfulness, Cognitive Decline (Age-Related), Forgetfulness (Benign Senescent), Memory Decline (Age-Consistent)
  • Reliable and relatively consistent scientific data showing a substantial health benefit.
  • Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
  • For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

SupplementAmountWhy
Acetyl-L-Carnitine
1,500 mg daily3 stars[3 stars] Several clinical trials suggest that this supplement delays onset of ARCD and improves overall cognitive function in the elderly
Ginkgo
120 to 160 daily3 stars[3 stars] Most, but not all, clinical trials have found this herb to be a safe and effective treatment for ARCD.
Phosphatidylserine
300 mg daily of bovine-derived supplement 3 stars[3 stars] Bovine-derived PS (phosphatidylserine) has been shown to improve memory, cognition, and mood in the elderly. To date, most evidence suggests that soy-derived PS is not effective for ARCD.
Vinpocetine
30 to 60 mg daily3 stars[3 stars] Vinpocetine has been shown to improve dementia symptoms in patients with various brain diseases.
Bacopa
Refer to label instructions 2 stars[2 stars] Animal studies have found this Ayurvedic herb enhances several aspects of mental function and learning ability, and there is some preliminary research that it improves mental function in humans.
Folic Acid
800 mcg per day 2 stars[2 stars] Folic acid has been shown to slow the rate of cognitive decline in people with high homocysteine levels.
Huperzia
100 to 150 mcg two to three times per day 2 stars[2 stars] Huperzine A, an extract from a Chinese medicinal herb, has been found to improve cognitive function in seniors with memory disorders.
Pycnogenol
150 mg per day 2 stars[2 stars] A study of healthy senior people reported that supplementing daily with Pycnogenol improved some measures of memory after three months, compared with a group taking a placebo.
Vitamin B12
(Vitamin B12 Deficiency)
Consult a qualified healthcare practitioner2 stars[2 stars] Improved brain function among seniors has been observed after correcting vitamin B12 deficiency with injections, but oral vitamin B12 has not been studied for ARCD. People with ARCD should be tested for vitamin B12 deficiency.
Vitamin B6
20 mg daily2 stars[2 stars] There is evidence that supplementing with vitamin B6 (pyridoxine) may improve memory performance, especially in people who are deficient.
Beta-Carotene
50 mg every other day 1 star[1 star] In one study, long-term beta-carotene supplementation slowed the loss of cognitive function in middle-aged healthy males.
Melatonin
Refer to label instructions 1 star[1 star] Cognitive function is linked to adequate sleep and normal sleep-wake cycles, which are partially regulated by the hormone melatonin. The long-term effects of melatonin are unknown, use under a doctor’s supervision.
Vitamin B6, Vitamin B12, and Folic Acid
(for women with low dietary intake )
Refer to label instructions 1 star[1 star]

In a study of women with cardiovascular disease or related risk factors, supplementing daily with folic acid, vitamin B6, and vitamin B12 appeared to prevent age-related cognitive decline in those with low dietary intake.

Vitamin C
Refer to label instructions 1 star[1 star] Use of vitamin C, alone or with vitamin E, has been associated with better cognitive function and a reduced risk of certain forms of dementia (not including Alzheimer’s disease).
Vitamin E
Refer to label instructions 1 star[1 star] Use of vitamin E, alone or with vitamin C, has been associated with better cognitive function and a reduced risk of certain forms of dementia (but not Alzheimer’s disease).


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Copyright © 2011 Aisle7.

Learn more about Aisle7, the company.

Learn more about the authors of Aisle7 products.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.

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