I am 49yrs old. I had a complete hysterectomy in 2008 and my doctor immediately put me on Premarin 0.625MG. I had never experienced any hot flashes in my life. I decided to try AM/PM Menopause Formula--the natural formula, to save on cost. I am on week two and everynight I am waking up sweating so bad that my hair is wet and I have to get up for a while to cool off, and this may happen up to 3 times during the night. My daytime seems to be better. I am not sure if it's the enzmatic, but in the last couple of days, it seems that I am more alert with more energy. The box says this may take 4-5 weeks to take affect which I am hoping because I cannot take the hot flashes.