“Indigestion” refers to any number of gastrointestinal complaints, which can
include gas (belching, flatulence, or bloating) and upset stomach. “Heartburn”
refers to a burning feeling that can be caused by stomach acid regurgitating into the
esophagus from the stomach, by gastritis
(inflammation of the lining of the stomach), or by an ulcer of the stomach or duodenum (also
called peptic ulcer). “Low stomach
acidity” refers to the inability to produce adequate quantities of stomach acid that
will affect digestion and absorption of nutrients.
In some cases, such as lactose intolerance,
symptoms of indigestion are due to a specific cause that requires specific treatment.
Sometimes symptoms associated with indigestion are caused by diseases unrelated to the
gastrointestinal tract. For example, ovarian
cancer may cause a sensation of bloating. Anyone with symptoms of indigestion should be
properly diagnosed by a healthcare professional before assuming that the information below is
applicable to their situation.
The most common cause of heartburn is gastroesophageal reflux disease (GERD), in which the sphincter between the esophagus
and the stomach is not functioning properly. Another, related cause of heartburn is hiatal
hernia, in which a small portion of the stomach protrudes through the aforementioned
sphincter.
According to Jonathan Wright, MD, another cause of heartburn can be too little
stomach acid.1 This may seem to be a paradox, but based on the clinical experience
of a few doctors such as Dr. Wright, supplementing with betaine HCl (a compound that contains hydrochloric
acid) often relieves the symptoms of heartburn and improves digestion, at least in people who
have hypochlorhydria (low stomach acid). The amount of betaine HCl used varies with the size
of the meal and with the amount of protein ingested. Typical amounts recommended by doctors
range from 600 to 2,400 mg per meal. Use of betaine HCl should be monitored by a healthcare
practitioner and should be considered only for indigestion sufferers who have been diagnosed
with hypochlorhydria.
Medical researchers since the 1930s have been concerned about the consequences of
hypochlorhydria. While all the health consequences are still not entirely clear, some have
been well documented.
Many minerals and vitamins appear to require adequate concentrations of stomach acid to be
absorbed optimally—examples are
iron,2 zinc,3 and B-complex vitamins,4 including folic acid.5 People with achlorhydria
(no stomach acid) or hypochlorhydria may therefore be at risk of developing various
nutritional deficiencies, which could presumably contribute to the development of a wide range
of health problems.
One of the major functions of stomach acid is to initiate the digestion of large protein
molecules. If this digestive function is not performed efficiently, incompletely digested
protein fragments may be absorbed into the bloodstream. The absorption of these large
molecules may contribute to the development of
food allergies and immunological disorders.6 7
In addition, stomach acid normally provides a barrier against bacteria, fungi, and other
organisms that are present in food and water. People with inadequate stomach acidity may
therefore be at risk of having “unfriendly” microorganisms colonize their
intestinal tract.8 9 Some of these organisms produce toxic substances
that can be absorbed by the body.
Some researchers have found that people with certain diseases are more likely to have an
inability to produce normal quantities of stomach acid. However, this does not mean these
diseases are caused by too little stomach acid. Jonathan Wright, MD, usually tests
patients’ stomach acid if they suffer from food allergies, arthritis (both rheumatoid arthritis and osteoarthritis), pernicious anemia (too little vitamin B12), asthma,
diabetes, vitiligo, eczema, tic douloureux, Addison’s disease, celiac disease, lupus erythematosus, or thyroid
disease.10