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Propranolol

Brand Name: Betachron®, Inderal®

Combination drug: Inderide®

Propranolol Information

is a beta-blocker drug. is used to treat or prevent some heart conditions, reduce the symptoms of angina pectoris (chest pain), lower blood pressure in people with hypertension, and improve survival after a heart attack. is sometimes used to prevent migraine headaches, to reduce movement associated with essential tremor, and to reduce performance anxiety.

Summary of Interactions with Vitamins, Herbs, and Foods
(for details about the summarized interactions, read the full article)

Beneficial May be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them.

Coenzyme Q10*

Beneficial May be Beneficial: Side effect reduction/prevention—Taking these supplements may help reduce the likelihood and/or severity of a potential side effect caused by the medication.

Coenzyme Q10*

Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.

High-potassium foods*

Pleurisy root*

Potassium supplements*

Tobacco

Check Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details.

Pepper

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Propranolol Interactions with Dietary Supplements

Coenzyme Q10
inhibits enzymes dependent on coenzyme Q10 (CoQ10). In one trial, propranolol-induced symptoms were reduced in people given 60 mg of CoQ10 per day.1

Potassium
Some beta-adrenergic blockers (called “nonselective” beta blockers) decrease the uptake of potassium from the blood into the cells,2 leading to excess potassium in the blood, a potentially dangerous condition known as hyperkalemia.3 People taking beta-blockers should therefore avoid taking potassium supplements, or eating large quantities of fruit (e.g., bananas), unless directed to do so by their doctor.

Propranolol Interactions with Herbs

Pepper (Piper nigrum, Piper longum)
In a single-dose human study, piperine, a chemical found in black pepper and long pepper, was reported to increase blood levels of propranolol,4 which could increase the activity and risk of side effects of the drug.

Pleurisy root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as beta-blockers.5

Propranolol Interactions with Foods and Other Compounds

Food
Food increases the absorption of propranolol.6 should be taken at the same time every day, always with or always without food. High-protein foods may interfere with propranolol metabolism, increasing propranolol blood levels and activity.7

Alcohol
may cause drowsiness or dizziness.8 Alcohol may intensify this action. To prevent accidental injury, people taking propranolol should avoid alcohol.

Tobacco
In a double-blind study of ten cigarette smokers with angina treated with propranolol for one week, angina episodes were significantly reduced during the nonsmoking phase compared with the smoking phase.9 People with angina taking propranolol who do not smoke should avoid starting. Those who smoke should consult with their prescribing doctor about quitting.



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Medication Reviews & Side Effects for Propranolol



  Write an online review of Propranolol
Review Date: 9/12/2007
Medication: Propranolol - - I Love It
Medication Type: Generic
Length Taken: More than 1 year
Strength: 80 mg X 3 times per day
Side Effects: Dizziness, Tollerance (Need to raise dose), Loss of Energy
Other Products Taken: no

I've been on Propranolol for over 8 years. I have a rapid, skipping heartbeat and tremors related to an overactive Thyroid disorder that went untreated for over 10 years. I now have a permanent heart problem. My doctor put me on Propranolol after my second child was born and this medication has helped me tremendously. It helped regulate my moods, since the high heart rate was causing me to feel anxious. The tremors in my hands have improved and will go away completely as long as I take this medication. The side effects I have is being cold at times, a bit dizzy, and tired since my dose is pretty high. Though I get tired more easily it beats being sick all the time with my heart. I recommend this pill and will probalby be on it for life.

Anonymous
Pittsburgh, PA
USA

Review Date: 9/8/2008
Medication: Propranolol - - I Love It
Medication Type: Generic
Length Taken: More than 1 year
Strength: 60 mg X 1 times per day
Side Effects: Dizziness, Loss of Sleep, Weight Gain
Other Products Taken: No

I have been taking Propranolol for 22 years now. It is the only medication that I have ever taken regularly. I take it to control tachycardia and PVC's that I developed at 20 years of age. I don't know how I could live w/out this medicine. With it I can live very normally, without it I can barely walk, lift up my arms, do anything without my heart racing wildly. Apparently I have an overactive AV node in my heart which over reacts with normal activity. Anyway, I thank goodness that there is a drug that can control my symptoms as well as Inderal does. The only side effects that I have had all of these years are crazy dreams, occasional light-headedness at times and I believe that it makes me not only gain weight but also make it nearly impossible to lose it. I have gained approx 30 pounds over these last 22 years and cannot lose it despite disciplined dieting and moderate exercise. I have read that Inderal has the associated symptom of weight gain and the difficulty of losing the weight. But the risks or side effects definitely are outweighed by the benefits of taking the Inderal; for me anyway.

Kim Lane
Dover, Delaware USA



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