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Piroxicam Information
Summary of
Interactions with Vitamins, Herbs, and Foods
(for details about the summarized interactions, read the full article)
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
Lithium*
Potassium*
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Check: Other—Before taking any of these supplements or eating any of
these foods with your medication, read this article in full for details. |
Folic acid*
Willow*
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| Depletion or interference |
None known
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| Side effect reduction/prevention |
None known
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| Supportive interaction |
None known
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| Reduced drug
absorption/bioavailability |
None known
|
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Piroxicam Interactions with Dietary Supplements
Potassium
An 85-year-old man developed higher than normal blood levels of potassium following several
months of treatment with piroxicam.1 Until more is known, people taking piroxicam
for long periods should have their blood checked regularly for high potassium levels and may
need to avoid high potassium intake with the guidance of a health practitioner.
Folic
acid
may prevent inflammation by blocking the activity of enzymes that depend on folic
acid.2 However, other studies show that people taking NSAIDs such as aspirin have lower than normal levels of folic acid in
their red blood cells.3 Further research is needed to determine whether
supplemental folic acid prevents a deficiency of the vitamin or indirectly reduces the
beneficial effects of piroxicam.
Lithium
Lithium is a mineral that is present in some supplements and is also used in large amounts to
treat mood disorders such as bipolar disorder
(manic depression). Blood levels of lithium may increase in people taking NSAIDs and lithium supplements together (compared with
lithium alone),4 possibly resulting in unwanted side effects such as diarrhea, nausea, muscle weakness, and lack of
coordination. More research is needed to determine whether piroxicam specifically increases
lithium blood levels. Until more is known, people should avoid lithium supplementation except
when it is prescribed by a doctor.
Piroxicam Interactions with Herbs
Willow
(Salix alba)
Willow bark contains salicin, which is related to
aspirin. Both salicin and aspirin produce anti-inflammatory effects after they have been
converted to salicylic acid in the body. Taking aspirin significantly lowers blood levels of
piroxicam and increases the potential for adverse side effects.5 Though no studies
have investigated interactions between willow bark and piroxicam, people taking the drug
should avoid the herb until more information is available.
Piroxicam Interactions with Foods and Other Compounds
Food
Taking piroxicam with a meal may delay the speed, but not the overall amount, of drug
absorption.6 Therefore, it may be taken with food if stomach upset occurs when
taking the drug on an empty stomach.
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Review Date: 10/28/2008
Medication: Piroxicam -  - Stay Far Away
Medication Type: Generic
Length Taken: Less than 1 month
Strength: 20 mg X 1 times per day
Side Effects: Headache, Dry Mouth, Stomach Pain, Constipation, Gave Me Gas or Made Me Bloated, Sexual Dysfunction
Other Products Taken:
I have suffered many side affects from it. Swelling of feet and eyes. Severe headaches, blurred vision and bruising of the skin.
Anonymous
Fort Myers, FL
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Learn more about the authors of Using Medicines
with Vitamins and Herbs
The information presented in Healthnotes is for informational
purposes only. It is based on scientific studies (human, animal, or in vitro),
clinical experience, or traditional usage as cited in each article. The results reported may
not necessarily occur in all individuals. For many of the conditions discussed, treatment with
prescription or over-the-counter medication is also available. Consult your doctor,
practitioner, and/or pharmacist for any health problem and before using any supplements or
before making any changes in prescribed medications. The "reviews" listed for any medical condition, prescription drug, condition or symtpom is provided specifically from eVitamins and is not associated with healthnotes.
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