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Doxylamine

Brand Name: Decapryn®, Nighttime Sleep Aid®, Sleep Aid®, Unisom®

Doxylamine Information

is an antihistamine used for short-term treatment of insomnia. is available alone in a nonprescription product for sleep and in combination with nonprescription drugs to treat symptoms of allergy, colds, and upper respiratory infections.

Summary of Interactions with Vitamins, Herbs, and Foods
(for details about the summarized interactions, read the full article)

Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.

Henbane*

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Doxylamine Interactions with Herbs

Henbane (Hyoscyamus niger)
Antihistamines, including doxylamine, can cause “anticholinergic” side effects such as dryness of mouth and heart palpitations. Henbane also has anticholinergic activity and side effects. Therefore, use with doxylamine could increase the risk of anticholinergic side effects;1 however, apparently no interactions have yet been reported with doxylamine and henbane. Henbane should not be taken except by prescription from a physician trained in its use, as it is extremely toxic.

Doxylamine Interactions with Foods and Other Compounds

Alcohol
causes drowsiness.2 Alcohol may intensify this effect and increase the risk of accidental injury.3 To prevent problems, people taking doxylamine or doxylamine-containing products should avoid alcohol.



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