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Misoprostol

Brand Name: Cytotec®

Combination drug: Arthrotec®

Misoprostol Information

is a type of drug called a prostaglandin E1 analog that protects the mucosal lining of the stomach and intestines. It is either used alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) to prevent injury to stomach and intestinal tissue caused by these agents.

Summary of Interactions with Vitamins, Herbs, and Foods
(for details about the summarized interactions, read the full article)

Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.

Magnesium

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Misoprostol Interactions with Dietary Supplements

Magnesium
A common side effect of misoprostol is diarrhea, which is aggravated by taking magnesium.1 Consequently, individuals who experience diarrhea while taking misoprostol should avoid magnesium supplementation.

Misoprostol Interactions with Foods and Other Compounds

Food
Taking misoprostol with food may lower the maximum concentration of the drug in the blood and delay (though not decrease) absorption up to ten hours.2 3 However, since ingestion of food with misoprostol may reduce the incidence of diarrhea, it is usually recommended that the drug be taken with a meal.4



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