Brand Name: Ocatmide®, Reglan®
Metoclopramide Information
is used to treat heartburn
and regurgitation; to prevent vomiting in people receiving drugs to treat cancer; and to
prevent nausea, vomiting, heartburn, and fullness after a meal in certain individuals with diabetes.
Summary of
Interactions with Vitamins, Herbs, and Foods
(for details about the summarized interactions, read the full article)
 May be Beneficial: Supportive
interaction—Taking these supplements may support or otherwise help your medication
work better. |
Willow*
|
Avoid: Adverse interaction—Avoid these supplements when taking this
medication because taking them together may cause undesirable or dangerous results. |
N-acetyl cysteine*
|
| Depletion or interference |
None known
|
| Side effect reduction/prevention |
None known
|
| Reduced drug
absorption/bioavailability |
None known
|
An asterisk (*) next to an item in the summary indicates that the
interaction is supported only by weak, fragmentary, and/or contradictory scientific
evidence.
Metoclopramide Interactions with Dietary Supplements
N-acetyl
cysteine
A single case report described a 15-year-old girl who suffered oxygen deprivation in her body
tissues after being given high amounts of metoclopramide and N-acetyl-cysteine to treat her
for an overdose of acetaminophen.1
It is unknown whether N-acetyl-cysteine supplementation in the absence of acetaminophen
overdose could cause similar effects in people taking metoclopramide. Until controlled
research determines the safety of this combination, it should be used only under the
supervision of a qualified physician.
Metoclopramide Interactions with Herbs
Willow
(Salix alba)
Salicylic acid is a compound formed in the body from either aspirin or willow bark. Taking metoclopramide before
aspirin or willow bark results in higher concentrations of salicylic acid and greater pain
relief in people suffering from an acute migraine headache.2 Controlled studies are
necessary to confirm the benefit of this interaction.
Interaction with Foods and Other Compounds –––
Lactose-containing foods
Individuals who have lactose intolerance
(difficulty digesting milk sugar) may experience more severe symptoms while taking
metoclopramide.3 Lactose is the milk sugar present in dairy products.
Caffeine
A single case report described a 42-year-old man taking metoclopramide who experienced mental
depression after he abruptly quit using
caffeine.4 People who are advised to quit caffeine should probably reduce their
coffee or tea consumption gradually if they are taking metoclopramide.
Alcohol
Drinking alcohol while taking metoclopramide may significantly increase the amount and speed
of alcohol absorption, resulting in enhanced alcohol effects such as drowsiness.5
Consequently, people taking metoclopramide should avoid alcohol, especially when staying alert
is necessary.
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Learn more about the authors of Using Medicines
with Vitamins and Herbs
The information presented in Healthnotes is for informational
purposes only. It is based on scientific studies (human, animal, or in vitro),
clinical experience, or traditional usage as cited in each article. The results reported may
not necessarily occur in all individuals. For many of the conditions discussed, treatment with
prescription or over-the-counter medication is also available. Consult your doctor,
practitioner, and/or pharmacist for any health problem and before using any supplements or
before making any changes in prescribed medications. The "reviews" listed for any medical condition, prescription drug, condition or symtpom is provided specifically from eVitamins and is not associated with healthnotes.
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