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Benzodiazepines

Brand Name: Ativan®, Bromazepam, Centrax®, Chlordiazepoxide, Clonazepam, Clorazepate, Dalmane®, Diastat®, Diazepam, Dizac™, Doral®, Estazolam, Flunitrazepam, Flurazepam, Halazepam, Klonopin®, Libritabs®, Librium®, Loprazolam, Lorazepam, Lormetazepam, Midazolam, Nitrazepam, Paxipam®, Prazepam, ProSom®, Quazepam, Restoril®, Temazepam, Valium®, Versed®

Benzodiazepines Information

are a family of drugs used to treat insomnia, anxiety, panic attacks, muscle spasms, and seizure disorders. One benzodiazepine, midazolam, is used as a general anesthetic.

Interactions involving benzodiazepines in general are described on this page. For interactions involving a specific benzodiazepine, refer to the highlighted drugs listed below.

  • Alprazolam (Xanax®)
  • Chlordiazepoxide (Librium®, Libritabs®)
  • Clonazepam (Klonopin®)
  • Clorazepate Dipotassium (Tranxene®)
  • Diazepam (Valium®)
  • Estazolam (ProSom®)
  • Flunitrazepam (Rohypnol®)
  • Flurazepam (Dalmane®)
  • Lorazepam (Ativan®)
  • Midazolam (Versed®)
  • Oxazepam (Serax®)
  • Quazepam (Doral®)
  • Temazepam (Restoril®)
  • Triazolam (Halcion®)

Summary of Interactions with Vitamins, Herbs, and Foods
(for details about the summarized interactions, read the full article)

Beneficial May be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better.

Vinpocetine

Avoid Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results.

Alcohol

St. John's wort (alprazolam)

Depletion or interference

None known

Side effect reduction/prevention

None known

Reduced drug absorption/bioavailability

None known

Interactions common to many, if not all, are described in this article. Interactions reported for only one or several drugs in this class may not be listed in this article. Some drugs listed in this article are linked to articles specific to that respective drug; please refer to those individual drug articles. The information in this article may not necessarily apply to drugs in this class for which no separate article exists. If you are taking a Benzodiazepine for which no separate article exists, talk with your doctor or pharmacist.

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Benzodiazepines Interactions with Dietary Supplements

Vinpocetine
In a preliminary trial, an extract of periwinkle called vinpocetine was shown to produce minor improvements in short-term memory among people taking flunitrazepam, a benzodiazepine.1 Further study is needed to determine if vinpocetine would be a helpful adjunct to use of benzodiazepines.

Benzodiazepines Interactions with Herbs

Kava (Piper methysticum)
Kava is an herb used to treat anxiety disorder. One individual who took a benzodiazepine (alprazolam) and kava together, along with two other medications (cimetidine and terazosin) was hospitalized in a lethargic and disoriented condition.2 Further research is needed to determine whether the combination of kava and benzodiazepines produces an adverse interaction. However, individuals should not take benzodiazepines and kava together unless supervised by a doctor.

St. John's wort (Hypericum perforatum)
In a study of healthy volunteers, administration of St. John's wort along with alprazolam decreased blood levels of alprazolam, compared with the levels when alprazolam was taken by itself.3 Individuals taking alprazolam should not take St. John's wort without supervision by a doctor.

Benzodiazepines Interactions with Foods and Other Compounds

Alcohol
Drinking alcoholic beverages while taking benzodiazepines may increase side effects, such as drowsiness, confusion, and dizziness;4 if taken in excess, this combination may result in death. Consequently, people taking benzodiazepines should avoid drinking alcohol.



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Medication Reviews & Side Effects for Benzodiazepines



  Write an online review of Benzodiazepines
Review Date: 2/9/2007
Medication: Clonazepam - - I Love It
Medication Type: Generic
Length Taken: More than 1 year
Strength: .25 X 1 times per day
Side Effects: Dry Mouth
Other Products Taken: none

I take .25 mg prior to bed approx. 1/2 hour before sleep. It gently relaxes - usually it will give you a good night sleep without interruption. If you have to get up in the middle of the night, you can easily go back to sleep. If the dosage is not right for your body, you may experience a dry mouth and a bit sleepiness in the morning. You should allow at least 7 hours for sleeping. Also I have noticed that when the tablet is broken in half, it seems to lose potency. Otherwise it is a great way to get a good nights sleep and feel refreshed in the morning.

Anonymous
Shelby Twp, MI
USA

Review Date: 11/6/2007
Medication: Benzodiazepines - - Stay Far Away
Medication Type: Generic
Length Taken: More than 1 year
Strength: 2 mg X 2 times per day
Side Effects: Addiction, Tollerance (Need to raise dose)
Other Products Taken: No

Benzodiazepines are highly additive psychiatric drugs with withdrawal symptoms equal to opiates; like heroin for example. Do some investigations online before you begin using this medication. Googling "permanent brain damage; benzo" produces some interesting results.

Anonymous
Europe

Review Date: 3/17/2008
Medication: Atavan - - Stay Far Away
Medication Type: Brand Name
Length Taken: More than 1 year
Strength: 1/2 MG X 1 times per day
Side Effects: Anxiety, Headache, Nausea, Stomach Pain, Constipation, Paranoia, Addiction, Gave Me Gas or Made Me Bloated, Loss of Sleep, Made Me Nauseous
Other Products Taken:

I have been trying to get off Lorazapam(Atavan)since Jan. after being on it for 2 1/2 yrs. I realize I went the wrong way, through a doctor, by trying other medications, including Diazapam, Trazodone, Dramamine, & now I'm back on 1/2 MG Lorazapam at night, along with 6.25 MG of Ambien, through a doctor. I don't tolerate any medication well & I'm being affected by it with my thinking & general well being. I was also put on Paroxetine, but took it one night with horrible side effects. Now I'm at the point, I don't know what to do, & don't think my doctor knows either. I just want to get off the drugs.

Lois Popanz
Hendersonville, NC USA


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