Powdered goldenseal root and rhizome, 4–6 grams per day in tablet or capsule form, is sometimes recommended. For liquid herbal extracts, use 2–4 ml three times per day. Alternatively, 250–500 mg three times per day of standardized extracts supplying 8–12% alkaloids, are suggested. Continuous use should not exceed three weeks, with a break of at least two weeks between each use.
Due to environmental concerns of overharvesting, many herbalists recommend alternatives to goldenseal, such as Oregon grape or goldthread.