Boric acid suppositories should not be used during pregnancy. Boric acid is very toxic when taken internally and should also never be used on open wounds. When boric acid enters the body, it can cause nausea, vomiting, diarrhea, dermatitis, kidney damage, acute failure of the circulatory system, and even death. In the past, boric acid was used as a topical treatment for infants with diaper rash. However, even in diluted (3%) form it caused significant toxicity and two deaths. Therefore, boric acid should not be applied to the skin of infants and small children. In fact, experts in the field have stated, “The minor therapeutic value of this compound, in comparison with its potential as a poison, has led to the general recommendation that it no longer be used as a therapeutic agent.” However, in more recent research, no serious side effects were reported when boric acid was used as a treatment for vaginitis.