Certain rare inborn diseases can leave people with depletion of biotin due to the inability to metabolize the vitamin normally. A dietary deficiency of biotin, however, is quite uncommon, even in those consuming a diet low in this B vitamin. Nonetheless, if someone eats large quantities of raw egg whites, a biotin deficiency can develop, because a protein in the raw egg white inhibits the absorption of biotin. Cooked eggs do not present this problem. Long-term antibiotic use can interfere with biotin production in the intestine and increase the risk of deficiency symptoms, such as dermatitis, depression, hair loss,anemia, and nausea. Long-term use of anti-seizure medications may also lead to biotin deficiency.Alcoholics and people with diseases of the stomach have been reported to show evidence of poor biotin status. However, the usefulness of biotin supplementation for these people remains unclear. In animals, and possibly in humans, biotin deficiency can cause birth defects. As biotin deficiency may occur in as many as 50% of pregnant women, it seems reasonable to use a prenatal multiple vitamin and mineral formula that contains biotin.