1. Di Bisceglie AM, Bonkovsky HL, Chopra S, et al. Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: a multicenter, prospective, randomized, controlled trial. Hepatology 2000;32:135–8.
2. Blum AL, Doelle W, Kortum K, et al. Treatment of acute viral hepatitis with (+)-cyanidanol-3. Lancet 1977;2:1153–5.
3. Suzuki H, Yamamoto S, Hirayama C, et al. Cianidanol therapy for HBs-antigen-positive chronic hepatitis: a multicentre, double-blind study. Liver 1986;6:35–44.
4. Bar-Meir S, Halpern Z, Gutman M, et al. Effect of (+)-cyanidanol-3 on chronic active hepatitis: A double blind controlled trial. Gut 1985;26:975–9.
5. Conn HO. Cyanidanol: will a hepatotrophic drug from Europe go west? Hepatology 1983;3:121–3.
6. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711–17.
7. Gong HY, Wang KQ, Tang SG. Effects of Cordyceps sinensis on T lymphocyte subsets and hepatofibrosis in patients with chronic hepatitis B. Hunan Yi Ke Da Xue Bao 2000;25:248–50 [in Chinese].
8. Zhou L, Yang W, Xu Y, et al. Short-term curative effect of cultured Cordycepssinensis (Berk.) Sacc. Mycelia in chronic hepatitis B. Zhongguo Zhong Yao Za Zhi 1990;15:53–5, 65 [in Chinese].
9. Zhu JL, Liu C. Modulating effects of extractum semen persicae and cultivated cordyceps hyphae on immuno-dysfunction of inpatients with posthepatitic cirrhosis. Zhongguo Zhong Xi Yi Jie He Za Zhi 1992;12:207–9,195 [in Chinese].
10. Suzuki H, Ohta Y, Takino T, et al. Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis. Double blind trial. Asian Med J 1983;26:423–38.
11. Yasuda K, Hino K, Fujioka S, et al. Effects of high dose therapy with Stronger Neo-Minophagen C (SNMC) on hepatic histography in non-A, non-B chronic active hepatitis. In Viral Hepatitis C, D, E, ed. T Shikata, RH Purcell, T Uchida. Amsterdam: Excerpta Medica, 1991, 205–9.
12. Crance JM, L’eveque F, Biziagos E, et al. Studies on mechanism of action on glycyrrhizin against hepatitis A virus replication in vitro. Antiviral Res 1994;23:63–76.
13. Su XS, Chen HM, Wang LH, et al. Clinical and laboratory observation on the effect of glycyrrhizin in acute and chronic viral hepatitis. J Trad Chin Med 1984;4:127–32.
14. Magliulo E, Gagliardi B, Fiori GP. Results of a double blind study on the effect of silymarin in the treatment of acute viral hepatitis carried out at two medical centres. Med Klin 1978;73:1060–5 [in German].
15. Bode JC, Schmidt U, Durr HK. Silymarin for the treatment of acute viral hepatitis? Report of a controlled trial. Med Klin 1977;72:513–8 [in German].
16. Vailati A, Aristia L, Sozze E, et al. Randomized open study of the dose-affect relationship of a short course of IdB 1016 in patients with viral or alcoholic hepatitis. Fitoterapia 1993;64:219–27.
17. Buzzelli G, Moscarella S, Giusti A, et al. A pilot study on the liver protective effect of silybinphosphatidylcholine complex (IdB 1016) in chronic active hepatitis. Int J Clin Pharmacol Ther Toxicol 1993;31:456–60.
18. Lirussi F, Okolicsanyi L. Cytoprotection in the nineties: experience with ursodeoxycholic acid and silymarin in chronic liver disease. Acta Physiol Hung 1992;80:363–7.
19. Schuppan D, Strösser W, Burkard G, Walosek G. Legalon® lessens fibrosing activity in patients with chronic liver diseases. Zeits Allgemeinmed 1998;74:577–84.
20. Yang DG. Comparison of pre- and post-treatmental hepatohistology with heavy dosage of Paeonia rubra on chronic active hepatitis caused liver fibrosis. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih 1994;14:195,207–9 [in Chinese].
21. Wang CB, Chang AM. Plasma thromboxane B2 changes in severe icteric hepatitis treated by traditional Chinese medicine—dispelling the pathogenic heat from blood, promoting blood circulation and administrating large doses of radix Paeoniae—a report of 6 cases. Chung Hsi I Chieh Ho Tsa Chih 1985;5:322,326–8 [in Chinese].
22. Thyagarajan SP, Subramian S, Thirunalasundari T, et al. Effects of Phyllanthus amarus on chronic carriers of hepatitis B virus. Lancet 1988;2:764–6.
23. Doshi JC, Vaidya AB, Antarkar DS, et al. A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers: Failure to eradicate the surface antigen. Indian J Gastroenterol 1994;13:7–8.
24. Leelarasamee A, Trakulsomboon S, Maunwongyathi P, et al. Failure of Phyllanthus amarus to eradicate hepatitis B surface antigen from symptomless carriers. Lancet 1990;335:1600–1.
25. Wang M, Cheng H, Li Y, et al. Herbs of the genus Phyllanthus in the treatment of chronic hepatitis B: observations with three preparations from different geographical sites. J Lab Clin Med 1995;126:350–2.
26. Frezza M, Centini G, Cammareri G, et al. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990;37 Suppl 2:122–5.
27. Frezza M, Surrenti C, Manzillo G, et al. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology 1990;99:211–5.
28. Hirayama C, Okumura M, Tanikawa K, et al. A multicenter randomized controlled clinical trial of Shosaiko-to in chronic active hepatitis. Gastroent Jap 1989;24:715–9.
29. Fujiwara K, Ohta Y, Ogata I, et al. Treatment trial of traditional Oriental medicine in chronic viral hepatitis. In: Ohta Y (ed) New Trends in Peptic Ulcer and Chronic Hepatitis: Part II. Chronic Hepatitis. Tokyo: Excerpta Medica, 1987, 141–6.
30. Tajiri H, Kozaiwa K, Osaki Y, et al. The study of the effect of sho-saiko-to on HBeAg clearance in children with chronic HBV infection and with abnormal liver function tests. Acta Paediatr Jpn 1991;94:1811–5.
31. Gibo Y, Nakamura Y, Takahashi N, et al. Clinical study of sho-saiko-to therapy for Japanese patients with chronic hepatitis C (CH-C). Prog Med 1994;14:217–9.
32. Gibo Y, Nakamura Y, Takahashi N, et al. Clinical study of sho-saiko-to therapy for Japanese patients with chronic hepatitis C (CH-C). Prog Med 1994;14:217–9.
33. Oka H, Yamamoto S, Kuroki T, et al. Prospective study of chemoprevention of hepatocellular carcinoma with sho-saiko-to (TJ-9). Cancer 1995;76:743–9.
34. Mizushima Y, Oosaki R, Kobayashi M. Clinical features of pneumonitis induced by herbal drugs. Phytother Res 1997;11:295–8.
35. Skotnicki AB. Therapeutic application of calf thymus extract (TFX). Med Oncol Tumor Pharmacother 1989;6:31–43 [review].
36. Galli M, Crocchiolo P, Negri C, et al. Attempt to treat acute type B hepatitis with an orally administered thymic extract (thymomodulin): Preliminary results. Drugs Exp Clin Res 1985;11:665–9.
37. Bortolotti F, Cadrobbi P, Crivellaro C, et al. Effect of an orally administered thymic derivative, thymomodulin, in chronic type B hepatitis in children. Curr Ther Res 1988;43:67–72.
38. Civeira MP, Castilla A, Morte S, et al. A pilot study of thymus extract in chronic non-A, non-B hepatitis. Aliment Pharmacol Ther 1989;3:395–401.
39. Wallace AE, Weeks WB. Thiamine treatment of chronic hepatitis B infection. Am J Gastroenterol 2001;96:864–8.
40. Takagi H, Nagamine T, Abe T, et al. Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J Viral Hepat 2001;8:367–71.
41. Hobbs, C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 96–107.
42. Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of Alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin 1999;94 Suppl 3:84–9.
43. Chaturvedi GN, Singh RH. Jaundice of infectious hepatitis and its treatment with an indigenous drug, Picrorhiza kurrooa [sic]. J Res Ind Med 1966;1:1–13.
44. Chaturvedi GN, Tomar GS, Tiwari SK, Singh KP. Clinical studies on kalmegh (Andrographis paniculata) in infective hepatitis. J Int Inst Ayurveda 1983;2:208–11.
45. Tang W, Eisenbrand G. Chinese Drugs of Plant Origin. Berlin: Springer Verlag, 1992.
46. Bone K, Morgan M. Clinical Applications of Ayurvedic and Chinese Herbs: Monographs for the Western Herbal Practitioner. Warwick, Australia: 1996.
47. Jenkins PJ, Portmann BP, Eddleston AL, Williams R. Use of polyunsaturated phosphatidylcholine in HBsAg negative chronic active hepatitis: Results of prospective double-blind controlled trial. Liver 1982;2:77–81.
48. Chaturvedi GN, Singh RH. Jaundice of infectious hepatitis and its treatment with an indigenous drug, Picrorhiza kurrooa [sic]. J Res Ind Med 1966;1:1–13.
49. Chaturvedi GN, Tomar GS, Tiwari SK, Singh KP. Clinical studies on kalmegh (Andrographis paniculata) in infective hepatitis. J Int Inst Ayurveda 1983;2:208–11.
50. Hobbs, C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 96–107.
51. Liu KT. Studies on fructus Schisandrae chinensis. Annex 12: Studies on fructus Schisandrae chinensis. Plenary lecture, World Health Organization Seminar on the Use of Medicinal Plants in Health Care, Sept 1977, Tokyo, Japan. In: WHO Regional Office for the Western Pacific Final Report, Manila, 1977, 101–12.
52. Chang HM, But P (eds). Pharmacology and Applications of Chinese Materia Medica vol 1. Singapore: World Scientific, 1986.
53. Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of Alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin 1999;94 Suppl 3:84–9.
54. Harada T, Kanetaka T, Suzuki H, Suzuki K. Therapeutic effect of LEM (extract of cultured Lentinus edodes mycelia) against HBeAg-positive chronic hepatitis B. Gastroenterol Int 1988;1(suppl 1):abstract 719.
55. Campbell RE, Pruitt FW. Vitamin B12 in the treatment of viral hepatitis. Am J Med Sci 1952;224:252–62.
56. Campbell RE, Pruitt FW. The effect of vitamin B12 and folic acid in the treatment of viral hepatitis. Am J Med Sci 1955;229:8–15.
57. Morishige F, Murata A. Vitamin C for prophylaxis of viral hepatitis B in transfused patients. J Int Acad Prev Med 1978;5(1):54–8.
58. Knodell RG, Tate MA, Akl BF, Wilson JW. Vitamin C prophylaxis for post transfusion hepatitis: lack of effect in a controlled trial. Am J Clin Nutr 1981;34:20–3.
59. Baur H, Staub H. Treatment of hepatitis with infusions of ascorbic acid: comparison with other therapies. JAMA 1954;156:565 [abstract].
60. Von Herbay A, Stahl W, Niederau C, et al. Diminished plasma levels of vitamin E in patients with severe viral hepatitis. Free Radic Res 1996;25:461–6.
61. Pan WH, Wang CY, Huang SM, et al. Vitamin A, vitamin E or beta-carotene status and hepatitis B-related hepatocellular carcinoma. Ann Epidemiol 1993;3:217–24.
62. Mezes M, Par A, Nemeth P, Javor T. Studies of the blood lipid peroxide status and vitamin E levels in patients with chronic active hepatitis and alcoholic liver disease. Int J Clin Pharmacol Res 1986;6:333–8.
63. Andreone P, Gramonzi A, Bernardi M. Vitamin E for chronic hepatitis B. Ann Intern Med 1998;128:156–7.
64. Houglum K, Venkataramani A, Lyche K, Chojkier M. A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology 1997;113:1069–73.
65. Look MP, Gerard A, Rao GS, et al. Interferon/antioxidant combination therapy for chronic hepatitis C—a controlled pilot trial. Antiviral Res 1999;43:113–22.
66. Yurdakok M, Kanra G. Vitamin E therapy in viral hepatitis. Mikrobiyol Bul 1986;20:91–4 [in Turkish].
67. Watanabe A, Okada K, Shimizu Y, et al. Nutritional therapy of chronic hepatitis by whey protein (non-heated). J Med 2000;31:283–302.
